Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, 229 Taibai North Road, Xi'an 710069, China; Department of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.
Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China.
Prog Lipid Res. 2018 Apr;70:17-28. doi: 10.1016/j.plipres.2018.04.002. Epub 2018 Apr 7.
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that has recently attracted increased attention. Accumulating studies have demonstrated that STAT3 plays an important role in various diseases, such as cancer and ischemic injury. In light of the distinctive effects of STAT3 on the regulation of metabolism and immune responses, we present the elaborate network of STAT3 in obesity. In this review, we first introduce the general background of STAT3, including a discussion regarding the STAT family and the characterization and regulation of STAT3. Then, we describe the STAT3 signaling network and its pathophysiological roles in lipid and glucose metabolism and immune function. Finally, we highlight the research progress regarding STAT3 in obesity. The information presented here may be useful for the design of future studies and may highlight the potential of STAT3 as a future therapeutic target for obesity.
信号转导子和转录激活子 3（STAT3）是一种转录因子，最近受到了越来越多的关注。越来越多的研究表明，STAT3 在各种疾病中发挥着重要作用，如癌症和缺血性损伤。鉴于 STAT3 对代谢和免疫反应调节的独特作用，我们提出了 STAT3 在肥胖中的精细调控网络。在这篇综述中，我们首先介绍了 STAT3 的一般背景，包括对 STAT 家族的讨论以及对 STAT3 的特征和调控的描述。然后，我们描述了 STAT3 信号网络及其在脂质和葡萄糖代谢以及免疫功能方面的病理生理作用。最后，我们强调了 STAT3 在肥胖中的研究进展。这里提供的信息可能对未来研究的设计有用，并突出了 STAT3 作为肥胖未来治疗靶点的潜力。
