Madej T H, Strunin L
Department of Anaesthesia, Foothills Hospital, University of Calgary, Alberta, Canada.
Anaesthesia. 1987 Nov;42(11):1156-61. doi: 10.1111/j.1365-2044.1987.tb05220.x.
Duration of analgesia and side effects following single bolus doses of epidural fentanyl (100 micrograms) or sufentanil (10, 20, 30 or 50 micrograms) were studied in 50 patients who underwent Caesarean section under epidural anaesthesia. Fewer patients experienced pain peroperatively in the fentanyl group than in a joint group of those given sufentanil 20 or 30 micrograms (p less than 0.05). The combined fentanyl and sufentanil 50 micrograms groups had fewer patients in pain than the sufentanil 10 micrograms group at 3 hours after injection (p less than 0.05). Patients given fentanyl also had a longer pain-free interval than those who received sufentanil 10 micrograms (p less than 0.02). The sufentanil 50 micrograms group had more patients asleep than the 10 micrograms group and also had more patients with pruritus than the 10 micrograms or 30 micrograms groups (p less than 0.02). The patients given sufentanil 30 and 50 micrograms had more emetic sequelae than those who received sufentanil 10 and 20 micrograms or fentanyl 100 micrograms (p less than 0.05). There was no detectable excretion of drug into breast milk and no significant respiratory depression at the time of first postoperative analgesia in the patients who received fentanyl or 30 micrograms or less of sufentanil.
对50例在硬膜外麻醉下接受剖宫产手术的患者，研究了单次推注硬膜外芬太尼（100微克）或舒芬太尼（10、20、30或50微克）后的镇痛持续时间和副作用。芬太尼组术中经历疼痛的患者少于给予20或30微克舒芬太尼的联合组（p<0.05）。芬太尼与50微克舒芬太尼联合组在注射后3小时疼痛的患者少于10微克舒芬太尼组（p<0.05）。给予芬太尼的患者无痛间隔时间也比接受10微克舒芬太尼的患者长（p<0.02）。50微克舒芬太尼组入睡的患者比10微克组多，且瘙痒的患者比10微克或30微克组多（p<0.02）。给予30和50微克舒芬太尼的患者比接受10和20微克舒芬太尼或100微克芬太尼的患者有更多的呕吐后遗症（p<0.05）。在接受芬太尼或30微克及以下舒芬太尼的患者中，术后首次镇痛时未检测到药物排泄到母乳中，也未出现明显的呼吸抑制。
