Division of Biomedical Engineering, Faculty of New Sciences and Technologies, University of Tehran, Karegar Ave., P.O. Box 14395-1561, Tehran, Iran.
School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Mater Sci Eng C Mater Biol Appl. 2018 Jul 1;88:88-94. doi: 10.1016/j.msec.2018.03.005. Epub 2018 Mar 11.
Various compositions and synthesis methods of biodegradable iron-based alloys have been studied aiming for the use of temporary medical implants. However, none is focused on nano-structured alloy and on adding antibacterial property to the alloy. In this study, new Fe-30Mn-(1-3)Ag alloys were synthesized by means of mechanical alloying and assessed for their microstructure, mechanical properties, corrosion rate, antibacterial activity and cytotoxicity. Results showed that the alloy with 3 wt% Ag content displayed the highest relative density, shear strength, micro hardness and corrosion rate. However, optimum cytotoxicity and the antibacterial activity were reached by the alloy with 1 wt% Ag content. The compositional and processing effects of the alloys' properties are further discussed in this work.
各种可生物降解铁基合金的组成和合成方法已经被研究，旨在用于临时医用植入物。然而，目前还没有研究集中在纳米结构合金和向合金中添加抗菌性能上。在这项研究中，通过机械合金化合成了新型的 Fe-30Mn-(1-3)Ag 合金，并对其微观结构、力学性能、腐蚀速率、抗菌活性和细胞毒性进行了评估。结果表明，含 3wt%Ag 的合金显示出最高的相对密度、剪切强度、显微硬度和腐蚀速率。然而，含 1wt%Ag 的合金具有最佳的细胞毒性和抗菌活性。本文进一步讨论了合金性能的成分和加工效应。
