Schinhammer Michael, Gerber Isabel, Hänzi Anja C, Uggowitzer Peter J
Laboratory of Metal Physics and Technology, Department of Materials, ETH Zurich, 8093 Zurich, Switzerland.
Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zurich, 8093 Zurich, Switzerland.
Mater Sci Eng C Mater Biol Appl. 2013 Mar 1;33(2):782-9. doi: 10.1016/j.msec.2012.11.002. Epub 2012 Nov 10.
Biodegradable iron-based alloys are potential candidates for application as temporary implant material. This study summarizes the design strategy applied in the development of biodegradable Fe-Mn-C-Pd alloys and describes the key factors which make them suitable for medical applications. The study's in vitro cytotoxicity tests using human umbilical vein endothelial cells revealed acceptable cytocompatibility based on the alloys' eluates. An analysis of the eluates revealed that Fe is predominantly bound in insoluble degradation products, whereas a considerable amount of Mn is in solution. The investigation's results are discussed using dose-response curves for the main alloying elements Fe and Mn. They show that it is mainly Mn which limits the cytocompatibility of the alloys. The study also supplies a summary of the alloying elements' influence on metabolic processes. The results and discussion presented are considered important and instructive for future alloy development. The Fe-based alloys developed show an advantageous combination of microstructural, mechanical and biological properties, which makes them interesting as degradable implant material.
可生物降解的铁基合金是作为临时植入材料应用的潜在候选者。本研究总结了在可生物降解的Fe-Mn-C-Pd合金开发中应用的设计策略，并描述了使其适用于医学应用的关键因素。该研究使用人脐静脉内皮细胞进行的体外细胞毒性测试表明，基于合金洗脱液，其细胞相容性是可接受的。对洗脱液的分析表明，铁主要结合在不溶性降解产物中，而大量的锰处于溶液中。使用主要合金元素铁和锰的剂量反应曲线对研究结果进行了讨论。结果表明，主要是锰限制了合金的细胞相容性。该研究还总结了合金元素对代谢过程的影响。所呈现的结果和讨论被认为对未来合金的开发具有重要意义和指导作用。所开发的铁基合金展现出微观结构、力学和生物学性能的有利组合，这使其作为可降解植入材料具有吸引力。
