Anderson J V, Raine A E, Proudler A, Bloom S R
J Endocrinol. 1986 Aug;110(2):193-6. doi: 10.1677/joe.0.1100193.
Twenty patients with chronic renal failure were studied before and after haemodialysis. Plasma atrial natriuretic peptide (ANP) concentrations were markedly elevated (P less than 0.01) before dialysis in comparison with healthy control subjects. After haemodialysis the plasma ANP concentration was lower in 19 patients (P less than 0.01) but remained above the normal range in all but three cases. Systolic and diastolic blood pressure and body weight fell during dialysis but none of these changes correlated with the reduction of the plasma ANP concentration. Chromatographic analysis of plasma extracts indicated that alpha-ANP is the predominant circulating molecular form. The increase in concentration of ANP in plasma between dialyses, at a time when many patients are susceptible to sodium and water overload, and its return towards normal after dialysis supports the putative role of ANP as a circulating factor released in response to sodium and water accumulation.
对20例慢性肾衰竭患者进行了血液透析前后的研究。与健康对照受试者相比，透析前血浆心钠素（ANP）浓度显著升高（P<0.01）。血液透析后，19例患者的血浆ANP浓度降低（P<0.01），但除3例患者外，其余患者的血浆ANP浓度均高于正常范围。透析期间收缩压和舒张压以及体重下降，但这些变化均与血浆ANP浓度的降低无关。血浆提取物的色谱分析表明，α-ANP是主要的循环分子形式。在许多患者易发生钠水潴留时，透析间期血浆ANP浓度升高，而透析后又恢复正常，这支持了ANP作为一种因钠水潴留而释放的循环因子的假定作用。
