Supriya Rashmi, Yung Benjamin Y, Yu Angus P, Lee Paul H, Lai Christopher W, Cheng Kenneth K, Yau Suk Y, Chan Lawrence W C, Sheridan Sinead, Siu Parco M
Department of Health Technology and Informatics, Hong Kong Polytechnic University, Kowloon, Hong Kong.
School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong.
Front Physiol. 2018 Mar 27;9:294. doi: 10.3389/fphys.2018.00294. eCollection 2018.
Central obesity and hypertension are common risk factors for the metabolic syndrome, cardiovascular and renal diseases. Studies have shown that it is more difficult to control blood pressure and prevent end-organ damage in obese individuals with hypertension compared to their non-obese counterparts, especially among women. Obese females have a 6 times higher risk of developing hypertension than non-obese females while obese males are at a 1.5 times higher risk of developing hypertension, compared to their non-obese counterparts. Indeed, the inter-relationship between obesity and hypertension is unclear. Adipokines have been proposed to play a mediating role in the relationship between obesity and hypertension and are involved in the pathogenesis of metabolic diseases. Therefore, this study sought to determine the role of adipokines (adiponectin, plasminogen activator inhibitor-1, leptin, and tumor necrosis factor-α) in hypertensive Hong Kong Chinese women with central obesity. A total of 387 women aged 58 ± 11 years who were examined with a 2 × 2 factorial design for central obesity (waist circumference ≥ 80 cm) and hypertension (blood pressure ≥ 140/90 mmHg), were recruited from a pool of 1,492 Hong Kong Chinese adults who were previously screened for metabolic syndrome. Subjects with hyperglycemia, hypertriglyceridemia, and dyslipidemia were excluded to eliminate confounding effects. Our findings revealed that hypertensive women with central obesity had a lower anti-inflammatory status (adiponectin) and a higher pro-inflammatory status (TNF-α) than obese alone or hypertensive alone women. Also, women with central obesity had higher circulatory PAI-1 and leptin concentrations than their non-obese counterparts. We conclude that obesity may shift toward a more pro-inflammatory state and may become more severe in the presence of hypertension or vice versa.
中心性肥胖和高血压是代谢综合征、心血管疾病和肾脏疾病的常见危险因素。研究表明，与非肥胖个体相比，肥胖的高血压患者更难控制血压并预防靶器官损害，尤其是在女性中。肥胖女性患高血压的风险是非肥胖女性的6倍，而肥胖男性患高血压的风险是非肥胖男性的1.5倍。事实上，肥胖与高血压之间的相互关系尚不清楚。脂肪因子被认为在肥胖与高血压的关系中起中介作用，并参与代谢疾病的发病机制。因此，本研究旨在确定脂肪因子（脂联素、纤溶酶原激活物抑制剂-1、瘦素和肿瘤坏死因子-α）在患有中心性肥胖的香港华裔高血压女性中的作用。从1492名曾接受代谢综合征筛查的香港华裔成年人中招募了387名年龄在58±11岁的女性，她们采用2×2析因设计进行中心性肥胖（腰围≥80cm）和高血压（血压≥140/90mmHg）检查。排除患有高血糖、高甘油三酯血症和血脂异常的受试者以消除混杂效应。我们的研究结果显示，患有中心性肥胖的高血压女性的抗炎状态（脂联素）较低，促炎状态（TNF-α）较高，高于单纯肥胖或单纯高血压的女性。此外，患有中心性肥胖的女性的循环PAI-1和瘦素浓度高于非肥胖女性。我们得出结论，肥胖可能会转向更促炎的状态，并且在存在高血压的情况下可能会变得更严重，反之亦然。
