FamPhy, Gurgaon 122101, India.
Public Health Foundation of India, Gurgaon 122001, India.
Nutrients. 2018 Apr 11;10(4):468. doi: 10.3390/nu10040468.
Several preventive strategies to reduce dyslipidemia have been suggested, of which dietary modification features as an important one. Dyslipidemia is a major risk factor for coronary heart disease and strategies to manage dyslipidemia have been shown to reduce the incidence of cardiovascular disease (CVD). Although there are proven pharmacological therapies to help manage this condition, nutritional interventions are a safer option to help prevent and manage dyslipidemia. Addition of almonds in the daily diet has been proposed to beneficially impact the lipid profile. This review critically examines the available evidence assessing the effect of almonds on dyslipidemia in the South Asian (particularly Indian) context. An extensive review comprised of epidemiological studies, clinical trials, meta-analyses, and systematic reviews was conducted from published literature from across the world. Studies examining the effect of almonds on different aspects of dyslipidemia viz. high low-density lipoprotein-cholesterol (LDL-C), low high-density lipoprotein-cholesterol (HDL-C), triglyceridaemia, and high total cholesterol levels have been included. In several studies, almonds have been shown to reduce LDL-C-which is a known risk factor for CHD-and the effect of almonds has been well documented in systematic reviews and meta-analysis of clinical trials. Addition of almonds in the diet has been shown to not only to reduce LDL-C levels, but also to maintain HDL-C levels. This review provides information about the use of this simple nutritional strategy which may help manage known major risk factors for heart disease, such as high LDL-C and low HDL-C levels especially in the context of South Asians.
已经提出了几种预防血脂异常的策略,其中饮食调整是一个重要策略。血脂异常是冠心病的主要危险因素,管理血脂异常的策略已被证明可以降低心血管疾病(CVD)的发生率。虽然有经过验证的药物治疗方法可以帮助控制这种情况,但营养干预是一种更安全的选择,可以帮助预防和控制血脂异常。在日常饮食中添加杏仁已被提议可以有益地影响血脂谱。本综述批判性地评估了评估杏仁对南亚(特别是印度)人群血脂异常影响的现有证据。从全球发表的文献中进行了广泛的综述,包括流行病学研究、临床试验、荟萃分析和系统评价。研究检查了杏仁对血脂异常不同方面的影响,即高低密度脂蛋白胆固醇(LDL-C)、低高密度脂蛋白胆固醇(HDL-C)、甘油三酯血症和总胆固醇水平升高。在几项研究中,杏仁已被证明可降低 LDL-C-这是冠心病的已知危险因素-杏仁的作用在临床试验的系统评价和荟萃分析中得到了很好的记录。在饮食中添加杏仁不仅可以降低 LDL-C 水平,还可以维持 HDL-C 水平。本综述提供了有关使用这种简单营养策略的信息,该策略可能有助于管理已知的心脏病主要危险因素,如高 LDL-C 和低 HDL-C 水平,特别是在南亚人群中。