Biro Izolda, Bubbear Judith, Donnelly Simon, Fattah Zozik, Sarkodieh James, Ranganathan Arun, Tahir Hasan
Clinical Research Unit, Department of Rheumatology, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
Trauma Case Rep. 2017 Nov 8;12:34-39. doi: 10.1016/j.tcr.2017.10.014. eCollection 2017 Dec.
Patients with Ankylosing Spondylitis (AS) are four times more likely to sustain spinal fractures. Due to the associated risk of neurological complications treatment is complex. We present the case of a 56-year-old Caucasian gentleman with AS who sustained a fracture of T2 vertebra following a traumatic hyperextension injury. He declined surgery in fear of complications and started treatment with subcutaneous Teriparatide at a dose of 20 mg daily for six months. There was complete healing of the vertebral fracture at 6 months without any complications. This case is unique as complete healing was achieved without preceding surgical intervention. Further exploration of the use of Teriparatide in spinal fractures in patients with AS is recommended to support the theories generated by this and other existing cases in the literature.
强直性脊柱炎（AS）患者发生脊柱骨折的可能性要高出四倍。由于存在神经并发症的相关风险，治疗较为复杂。我们报告一例56岁患有AS的白种男性患者，其在创伤性过伸损伤后发生T2椎体骨折。他因担心并发症而拒绝手术，并开始皮下注射特立帕肽治疗，剂量为每日20毫克，持续六个月。6个月时椎体骨折完全愈合，无任何并发症。该病例独特之处在于未进行前期手术干预就实现了完全愈合。建议进一步探索特立帕肽在AS患者脊柱骨折中的应用，以支持本病例及文献中其他现有病例所产生的理论。
