Department of Physics, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Department of Physics, University of Cambridge, Cambridge, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK; Department of Electrical Engineering, University of Cambridge, Cambridge, UK.
Lancet Gastroenterol Hepatol. 2018 May;3(5):349-362. doi: 10.1016/S2468-1253(18)30030-X. Epub 2018 Apr 6.
Barrett's oesophagus is an acquired metaplastic condition that predisposes patients to the development of oesophageal adenocarcinoma, prompting the use of surveillance regimes to detect early malignancy for endoscopic therapy with curative intent. The currently accepted surveillance regime uses white light endoscopy together with random biopsies, but has poor sensitivity and discards information from numerous light-tissue interactions that could be exploited to probe structural, functional, and molecular changes in the tissue. Advanced optical methods are now emerging that are highly sensitive to these changes and hold potential to improve surveillance of Barrett's oesophagus if they can be applied endoscopically. The next decade will see some of these exciting new methods applied to surveillance of Barrett's oesophagus in new device architectures for the first time, potentially leading to a long-awaited improvement in the standard of care.
巴雷特食管是一种获得性化生条件，使患者易患食管腺癌，因此需要进行监测，以便通过内镜治疗进行早期恶性肿瘤检测。目前接受的监测方案是使用白光内窥镜和随机活检，但敏感性差，并且丢弃了大量可能用于探测组织结构、功能和分子变化的光组织相互作用信息。目前正在出现的先进光学方法对这些变化非常敏感，如果可以在内窥镜下应用，有可能改善巴雷特食管的监测。未来十年，其中一些令人兴奋的新方法将首次应用于巴雷特食管的监测中，这些新方法将应用于新的设备架构中，这可能会带来期待已久的治疗标准的提高。
