Bhatia Madhu, Urolagin Shilpa Sarvesh, Pentyala Kishore Babu, Urolagin Sarvesh Basavaraj, K B Menaka, Bhoi Shreedevi
Private Practioner, Department of Periodontics, New you Cosmetic Clinic , Bangalore, Karnataka, India .
Lecturer, Department of Periodontics, Narsinhbhai Patel Dental College , North Gujarat, India.
J Clin Diagn Res. 2014 Dec;8(12):ZC65-9. doi: 10.7860/JCDR/2014/8231.5343. Epub 2014 Dec 5.
The aim of the present study was to evaluate the clinical and microbiological efficacy of locally delivered 1% curcumin gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis.
The study group consisted of 25 patients, belonging to both sex, aged between 21-45 years. All patients diagnosed as chronic periodontitis with periodontal pockets of depth >5mm bilaterally were randomly selected. A split mouth design was followed and the patients received a complete prophylaxis including scaling and root planing. Examination of plaque index, bleeding index, probing pocket depth and clinical attachment level were measured for each patient. The test group received 1% curcumin gel along with scaling and root planing whereas the control group received scaling and root planing alone followed by microbiological samples taken at baseline, 1, 3 and 6 months interval.
The 1% curcumin gel appeared to provide significant improvements in clinical parameters. Microbiological counts of Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum and capnocytophaga showed significant reduction in periopathogens at the test sites after six months when compared with that of control sites.
Locally delivered 1% curcumin gel was more effective in inhibiting the growth of oral bacteria when used as an adjunct to SRP in the treatment of chronic periodontitis.
本研究旨在评估局部应用1%姜黄素凝胶辅助龈下刮治和根面平整治疗慢性牙周炎的临床和微生物学疗效。
研究组由25名年龄在21 - 45岁之间的男女患者组成。所有双侧牙周袋深度>5mm且被诊断为慢性牙周炎的患者均被随机选取。采用半口设计，患者接受包括龈下刮治和根面平整在内的全面口腔预防治疗。测量每位患者的菌斑指数、出血指数、探诊牙周袋深度和临床附着水平。试验组在龈下刮治和根面平整的基础上接受1%姜黄素凝胶治疗，而对照组仅接受龈下刮治和根面平整治疗，随后在基线、1个月、3个月和6个月间隔时采集微生物样本。
1%姜黄素凝胶似乎能显著改善临床参数。与对照组部位相比，试验组部位在6个月后牙龈卟啉单胞菌、中间普氏菌、具核梭杆菌和嗜二氧化碳噬纤维菌的微生物计数显示牙周病原菌显著减少。
在治疗慢性牙周炎时，局部应用1%姜黄素凝胶作为龈下刮治和根面平整的辅助手段，在抑制口腔细菌生长方面更有效。
