21三体（唐氏综合征）淋巴母细胞样细胞上CD18的表达增加。
The expression of CD18 is increased on Trisomy 21 (Down syndrome) lymphoblastoid cells.
作者信息
Taylor G M, Williams A, D'Souza S W, Fergusson W D, Donnai D, Fennell J, Harris R
机构信息
Immunogenetics Laboratory, St Mary's Hospital, Manchester, UK.
出版信息
Clin Exp Immunol. 1988 Feb;71(2):324-8.
Abstract
The monoclonal antibody (MAB) 60.3 reacts with the beta chain (CD18) of lymphocyte function associated antigen (LFA-1), encoded by a gene on chromosome 21. We have used 60.3 to measure the expression of CD18 on lymphoblastoid cell-lines derived from persons with Trisomy 21 (Down syndrome) by quantitative fluorescence flow cytometric analysis. This showed that CD18 expression is increased on Trisomy 21 compared with normal cells, whereas neither HLA-class I, nor transferrin receptor expression are significantly affected. Similar results were obtained with the CD18 MAB MHM 23, and with the CD11a MAB MHM 24 (LFA-1 alpha). These results suggest that the increase in CD18 expression by Trisomy 21 cells is due to gene dosage, and could influence the immune status of persons with Down syndrome.
摘要
单克隆抗体（MAB）60.3与淋巴细胞功能相关抗原（LFA-1）的β链（CD18）发生反应，该抗原由21号染色体上的一个基因编码。我们通过定量荧光流式细胞术分析，使用60.3来测量源自21三体综合征（唐氏综合征）患者的淋巴母细胞系上CD18的表达。结果显示，与正常细胞相比，21三体综合征患者的细胞上CD18表达增加，而HLA-I类分子和转铁蛋白受体的表达均未受到显著影响。使用CD18单克隆抗体MHM 23以及CD11a单克隆抗体MHM 24（LFA-1α）也得到了类似结果。这些结果表明，21三体综合征细胞中CD18表达的增加是由于基因剂量所致，并且可能影响唐氏综合征患者的免疫状态。
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2
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