USI, Unit of Nanostructural Bio-Interactions, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Weigla-Street, 53-114 Wroclaw, Poland.
Trends Biotechnol. 2018 Sep;36(9):875-881. doi: 10.1016/j.tibtech.2018.03.002. Epub 2018 Apr 10.
Bacteriophages sense alkaline cations in their immediate extracellular environment, which regulates virion-virion interactions. An ion-steerable aggregation-dispersion (A/D) phenomenon among virions is a recently discovered step in group behavior in the phage life cycle. When powered by the octanol-based water-immiscible lipopolysaccharide (LPS) trap (oWILT) purification approach, A/D promises breakthroughs for a plethora of biotechnological applications beyond phage therapy.
噬菌体在其周围的细胞外环境中感知碱性阳离子，这调节了病毒粒子之间的相互作用。病毒粒子之间的离子可操纵的聚集-分散（A/D）现象是噬菌体生命周期中群体行为的一个新发现的步骤。当由基于辛醇的不混水脂多糖（LPS）陷阱（oWILT）纯化方法驱动时，A/D 有望为除噬菌体治疗之外的众多生物技术应用带来突破。
