Zemlin Annalise E
Division of Chemical Pathology, National Health Laboratory Service (NHLS) and University of Stellenbosch, Tygerberg Hospital, Cape Town, 7505 South Africa.
Indian J Clin Biochem. 2018 Apr;33(2):154-162. doi: 10.1007/s12291-017-0657-2. Epub 2017 May 5.
The total testing process consists of various phases from the pre-preanalytical to the post-postanalytical phase, the so-called brain-to-brain loop. With improvements in analytical techniques and efficient quality control programmes, most laboratory errors now occur in the extra-analytical phases. There has been recent interest in these errors with numerous publications highlighting their effect on service delivery, patient care and cost. This interest has led to the formation of various working groups whose mission is to develop standardized quality indicators which can be used to measure the performance of service of these phases. This will eventually lead to the development of external quality assessment schemes to monitor these phases in agreement with ISO15189:2012 recommendations. This review focuses on potential errors in the extra-analytical phases of clinical chemistry laboratory testing, some of the studies performed to assess the severity and impact of these errors and processes that are in place to address these errors. The aim of this review is to highlight the importance of these errors for the requesting clinician.
整个检测过程包括从分析前到分析后后阶段的各个阶段，即所谓的“脑到脑循环”。随着分析技术的改进和高效质量控制程序的实施，现在大多数实验室误差发生在分析外阶段。最近人们对这些误差产生了兴趣，大量出版物强调了它们对服务提供、患者护理和成本的影响。这种兴趣导致了各种工作组的形成，其任务是制定标准化质量指标，可用于衡量这些阶段的服务绩效。这最终将导致制定外部质量评估计划，以根据ISO15189:2012建议对这些阶段进行监测。本综述重点关注临床化学实验室检测分析外阶段的潜在误差、一些为评估这些误差的严重程度和影响而进行的研究以及为解决这些误差而采取的流程。本综述的目的是强调这些误差对申请临床医生的重要性。
