Sengupta Shreejita, Jaseem T, Ambalavanan Jayachidambaram, Hegde Anupama
1Kasturba Medical College, Manipal University, Mangaluru, Karnataka India.
2Department of Biochemistry, Center for Basic Sciences, Kasturba Medical College, Manipal University, Mangaluru, Karnataka 575004 India.
Indian J Clin Biochem. 2018 Apr;33(2):214-217. doi: 10.1007/s12291-017-0647-4. Epub 2017 Mar 18.
Despite various studies with conflicting results, the effect of thyroid hormones on lipids and insulin levels in dysthyroidism is of great interest. This case control study was aimed to perceive the existence of IR and dyslipidemia in mild subclinical hypothyroid subjects (TSH ≤ 9.9 µIU/ml) as compared to their age and gender matched euthyroid controls. Basic demographic information like height, weight was recorded. Serum samples of all the subjects were assayed for thyroid profile, lipid profile, blood glucose, HbA1C and insulin. BMI and insulin resistance was calculated. Compared to controls patients with mild subclinical hypothyroidism demonstrated hyperinsulinemia and dyslipidemia observed by the higher LDL cholesterol. A significantly positive correlation was observed for HOMA-IR with TSH and LDL cholesterol. Hence, even in the mild subclinical hypothyroid state assessment of thyroid function should be combined with estimation of plasma glucose, insulin and serum lipids to monitor and prevent its associated effects.
尽管各项研究结果相互矛盾，但甲状腺激素对甲状腺功能异常患者血脂和胰岛素水平的影响仍备受关注。本病例对照研究旨在了解轻度亚临床甲状腺功能减退患者（促甲状腺激素≤9.9 μIU/ml）与年龄和性别匹配的甲状腺功能正常对照者相比，是否存在胰岛素抵抗和血脂异常。记录身高、体重等基本人口统计学信息。对所有受试者的血清样本进行甲状腺功能、血脂、血糖、糖化血红蛋白和胰岛素检测。计算体重指数和胰岛素抵抗。与对照组相比，轻度亚临床甲状腺功能减退患者表现为高胰岛素血症和血脂异常，其低密度脂蛋白胆固醇水平较高。胰岛素抵抗指数与促甲状腺激素和低密度脂蛋白胆固醇呈显著正相关。因此，即使在轻度亚临床甲状腺功能减退状态下，甲状腺功能评估也应与血浆葡萄糖、胰岛素和血清脂质估计相结合，以监测和预防其相关影响。
