1 Biomedical Research Institute, International St. Mary's Hospital, Catholic Kwandong University , Incheon, Republic of Korea.
2 Department of Medical Science, College of Medicine, Catholic Kwandong University , Gangneung, Republic of Korea.
Tissue Eng Part A. 2018 Sep;24(17-18):1354-1363. doi: 10.1089/ten.TEA.2017.0470. Epub 2018 Jun 7.
Cutaneous wounds can present significant clinical problems because of abnormal healing after deep dermal damage. Despite technical advances in wound care, there are still unmet needs that result from inefficient treatment. In this study, we aimed to improve skin wound healing using a contractibility band with static magnetic field (SMF), termed a magnetic band (Mb). To examine the effect of the Mb on wound healing, full-thickness 15 × 35 mm excision wounds were surgically created on the dorsum of rats. An elastic and contractile band (nontreatment), or one neodymium magnet (Nd-1) or two magnets with an elastic and contractile band (Nd-2) were topically applied to the wound daily and the wound size was measured from day 1 to 7 after surgery. Nd-2 showed a significant (95%) reduction in the wound size on day 3. Histological analysis showed that proinflammatory cytokine levels were diminished by Nd-2, and granulation tissue and microvessels were increased compared with those in the sham group. During Mb-induced wound healing, apoptosis was significantly reduced and matrix remodeling-related factors were initially regulated. The results suggest that combination therapy comprising an SMF and an elastic and contractile band could be a promising tool to heal cutaneous wounds rapidly.
皮肤创伤会引发严重的临床问题，因为真皮深层损伤后的愈合会出现异常。尽管在伤口护理方面取得了技术进步，但由于治疗效果不理想，仍存在未满足的需求。在这项研究中，我们旨在使用具有静磁场（SMF）的可收缩带（称为磁带（Mb））来改善皮肤伤口愈合。为了研究 Mb 对伤口愈合的影响，在大鼠背部通过手术制造了全厚 15×35mm 的切除伤口。每天将弹性可收缩带（不治疗）或一个钕磁铁（Nd-1）或两个带弹性可收缩带的磁铁（Nd-2）应用于伤口表面，并在手术后第 1 天至第 7 天测量伤口大小。Nd-2 在第 3 天使伤口面积显著减少（95%）。组织学分析表明，Nd-2 降低了促炎细胞因子的水平，并增加了肉芽组织和微血管，与假手术组相比。在 Mb 诱导的伤口愈合过程中，细胞凋亡明显减少，基质重塑相关因子得到初步调节。结果表明，SMF 和弹性可收缩带的联合治疗可能是一种快速治愈皮肤创伤的有前途的工具。
