利尿剂、β-肾上腺素能受体阻滞剂及其联合应用对血压升高和血清钾的影响：一项交叉研究。
Effect of diuretic, beta-adrenoceptor blocking agent and their combination on elevated blood pressure and serum potassium: a cross-over study.
作者信息
Neuvonen P J, Pentikäinen P J, Jounela A J
出版信息
Br J Clin Pharmacol. 1978 Oct;6(4):363-7. doi: 10.1111/j.1365-2125.1978.tb00865.x.
Abstract
- The antihypertensive effect of a new beta-adrenoceptor blocking agent, trimepranol (10--14 mg/twice daily), chlorthalidone (50 mg every second day) and their combination was studied in eighteen patients with mild to moderate essential hypertension. In a controlled randomized cross-over study the drugs were given for 6 week periods. 2. A significant and equal decrease in blood pressure was achieved both with trimepranol and chlorthalidone, whereas their combination was significantly more effective. 3. Trimepranol significantly antagonized the chlorthalidone-induced hypokalemia. 4. The results favor the use of diuretic or diuretic-beta-adrenoceptor blocker combination over beta-adrenoceptor blocker monotherapy in the treatment of mild to moderate hypertension.
摘要
- 对18例轻至中度原发性高血压患者研究了一种新型β-肾上腺素能受体阻滞剂三甲丙醇（每日两次，每次10 - 14毫克）、氯噻酮（隔日50毫克）及其联合用药的降压效果。在一项对照随机交叉研究中，每种药物给药6周。2. 三甲丙醇和氯噻酮均使血压显著且同等程度下降，而二者联合用药效果显著更佳。3. 三甲丙醇可显著对抗氯噻酮所致的低钾血症。4. 结果表明，在治疗轻至中度高血压时，使用利尿剂或利尿剂 - β-肾上腺素能受体阻滞剂联合用药优于β-肾上腺素能受体阻滞剂单一疗法。
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