连接神经元谱系和连接特异性。

Department of Biology and Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

Neurosciences Graduate Program, Stanford University, Stanford, CA, 94305, USA.

Neural Dev. 2018 Apr 13;13(1):5. doi: 10.1186/s13064-018-0102-0.

Brain function requires precise neural circuit assembly during development. Establishing a functional circuit involves multiple coordinated steps ranging from neural cell fate specification to proper matching between pre- and post-synaptic partners. How neuronal lineage and birth timing influence wiring specificity remains an open question. Recent findings suggest that the relationships between lineage, birth timing, and wiring specificity vary in different neuronal circuits. In this review, we summarize our current understanding of the cellular, molecular, and developmental mechanisms linking neuronal lineage and birth timing to wiring specificity in a few specific systems in Drosophila and mice, and review different methods employed to explore these mechanisms.

大脑功能在发育过程中需要精确的神经回路组装。建立一个功能性的回路涉及多个协调步骤，从神经细胞命运特化到前后突触伙伴之间的正确匹配。神经元谱系和出生时间如何影响布线特异性仍然是一个悬而未决的问题。最近的研究结果表明，谱系、出生时间和布线特异性之间的关系在不同的神经元回路中是不同的。在这篇综述中，我们总结了我们目前对连接神经元谱系和出生时间与果蝇和小鼠中几个特定系统中布线特异性的细胞、分子和发育机制的理解，并回顾了探索这些机制所采用的不同方法。