Department of Molecular Biology, Biotechnology and Bioinformatics, CCS Haryana Agricultural University, Hisar, 125004, India.
J Nanobiotechnology. 2018 Apr 13;16(1):40. doi: 10.1186/s12951-018-0368-8.
Nanobiotechnology has the potential to revolutionize diverse sectors including medicine, agriculture, food, textile and pharmaceuticals. Disease diagnostics, therapeutics and crop protection strategies are fast emerging using nanomaterials preferably nanobiomaterials. It has potential for development of novel nanobiomolecules which offer several advantages over conventional treatment methods. RNA nanoparticles with many unique features are promising candidates in disease treatment. The miRNAs are involved in many biochemical and developmental pathways and their regulation in plants and animals. These appear to be a powerful tool for controlling various pathological diseases in human, plants and animals, however there are challenges associated with miRNA based nanotechnology. Several advancements made in the field of miRNA therapeutics make it an attractive approach, but a lot more has to be explored in nanotechnology assisted miRNA therapy. The miRNA based technologies can be employed for detection and combating crop diseases as well. Despite these potential advantages, nanobiotechnology applications in the agricultural sector are still in its infancy and have not yet made its mark in comparison with healthcare sector. The review provides a platform to discuss nature, role and use of miRNAs in nanobiotechnology applications.
纳米生物技术有可能彻底改变医学、农业、食品、纺织和制药等多个领域。疾病诊断、治疗和作物保护策略正在迅速采用纳米材料（最好是纳米生物材料）。它有潜力开发新型纳米生物分子，这些分子在常规治疗方法上具有许多优势。具有许多独特特征的 RNA 纳米颗粒是疾病治疗的有前途的候选物。miRNA 参与许多生化和发育途径，它们在植物和动物中的调节作用。这些似乎是控制人类、植物和动物各种病理疾病的有力工具，但是 miRNA 纳米技术相关的也存在一些挑战。miRNA 治疗领域的几项进展使其成为一种有吸引力的方法，但在纳米技术辅助 miRNA 治疗方面还有很多需要探索的地方。基于 miRNA 的技术也可用于检测和防治作物病害。尽管具有这些潜在优势，但与医疗保健部门相比，纳米生物技术在农业领域的应用仍处于起步阶段，尚未取得显著成绩。该综述提供了一个讨论 miRNA 在纳米生物技术应用中的性质、作用和用途的平台。
