Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China.
Cancer Lett. 2018 Jul 10;426:73-79. doi: 10.1016/j.canlet.2018.04.004. Epub 2018 Apr 11.
Initially identified as a cell and organ size controller, Hippo pathway turns into a hotspot for researchers. Within recent years, more and more mechanisms about Hippo pathway were uncovered. Even though Hippo signaling has been revealed to exert controversial roles according to different cell context and microenvironment, which is because of its diversified interplays with a great variety of signaling transduction cascades; mechanisms other than size-limitation, however, remain to be elucidated. Recently, a growing number of studies tend to put Hippo on inflammatory and immunological focus: its antimicrobial role in flies, its pro- or anti-inflammation in mammals, as well as its relevance to cancerous immunity. From inflammation to tumor immunogenicity, Hippo has been gradually justified to play a crucial role. This review summarized the latest findings regarding the involvement of Hippo pathway in immunity, and a more comprehensive understanding of Hippo pathway will shed light on clinical translational potential even precision medicine.
最初被确定为细胞和器官大小控制器的 Hippo 通路成为研究热点。近年来，越来越多的 Hippo 通路机制被揭示出来。尽管 Hippo 信号根据不同的细胞环境和微环境表现出有争议的作用，但这是由于它与多种信号转导级联的多样化相互作用；然而，除了大小限制之外的机制仍有待阐明。最近，越来越多的研究倾向于将 Hippo 置于炎症和免疫学的焦点上：它在果蝇中的抗菌作用，在哺乳动物中的促炎或抗炎作用，以及与癌症免疫的相关性。从炎症到肿瘤免疫原性，Hippo 逐渐被证明起着至关重要的作用。本文总结了 Hippo 通路在免疫中的最新发现，对 Hippo 通路的更全面理解将为临床转化潜力甚至精准医学带来启示。
