Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Department of Breast Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
Front Immunol. 2020 Feb 27;11:323. doi: 10.3389/fimmu.2020.00323. eCollection 2020.
Recognition of pathogen-associated molecular patterns (PAMPs) triggers expression of antiviral interferons and proinflammatory cytokines, which functions as the frontier of host defense against microbial pathogen invasion. Hippo-YAP pathway regulates cell proliferation, survival, differentiation and is involved in diverse life processes, including tissue homeostasis and tumor suppression. Emerging discoveries elucidated that the components of Hippo-YAP pathway, such as MST1/2, NDR1/2, and YAP/TAZ played crucial regulatory roles in innate immunity. Meanwhile the innate immune signaling also exhibited regulatory effect on Hippo-YAP pathway. As for the importance of these two pathways, it would be interesting to figure out the deeper biological implications of their interplays. This review focuses on the regulation between Hippo-YAP pathway and innate immune signaling. We also propose the possible contribution of these interplays to tumor development.
识别病原体相关分子模式 (PAMPs) 会触发抗病毒干扰素和促炎细胞因子的表达，这是宿主防御微生物病原体入侵的前沿。 Hippo-YAP 通路调节细胞增殖、存活、分化，并参与多种生命过程，包括组织稳态和肿瘤抑制。新的发现阐明了 Hippo-YAP 通路的组成部分，如 MST1/2、NDR1/2 和 YAP/TAZ，在先天免疫中发挥着关键的调节作用。同时，先天免疫信号也对 Hippo-YAP 通路表现出调节作用。鉴于这两条通路的重要性，了解它们相互作用的更深层次的生物学意义将是很有趣的。本综述重点介绍了 Hippo-YAP 通路与先天免疫信号之间的调节。我们还提出了这些相互作用可能对肿瘤发展的贡献。
