Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
Institute of Applied Sciences and Intelligent Systems "Edoardo Caianello" (ISASI), National Research Council of Italy, Messina, Italy; IRCCS "Bonino-Pulejo" Research Institute, SS 113, C.da Casazza, Messina, Italy.
Biotechnol Adv. 2018 Nov 1;36(6):1622-1632. doi: 10.1016/j.biotechadv.2018.04.001. Epub 2018 Apr 12.
Differentiation of cancer cells entails the reversion of phenotype from malignant to the original. The conversion to cell type characteristic for another tissue is named transdifferentiation. Differentiation/transdifferentiation of malignant cells in high grade tumor mass could serve as a nonaggressive approach that potentially limits tumor progression and augments chemosensitivity. While this therapeutic strategy is already being used for treatment of hematological cancers, its feasibility for solid malignancies is still debated. We will presently discuss the natural compounds that show these properties, with focus on anthraquinones from Aloe vera, Senna, Rheum sp. and hop derived prenylflavonoids.
癌细胞的分化需要表型从恶性向原始状态的逆转。将细胞类型转换为另一种组织特有的类型称为转分化。高级别肿瘤组织中恶性细胞的分化/转分化可以作为一种非侵袭性方法，潜在地限制肿瘤进展并增强化疗敏感性。虽然这种治疗策略已经用于治疗血液系统癌症，但它在实体恶性肿瘤中的可行性仍存在争议。目前，我们将讨论具有这些特性的天然化合物，重点是来自芦荟、番泻叶、大黄属和啤酒花的蒽醌类和类异戊二烯黄酮。
