嗜铬粒蛋白 A 及其衍生肽在肠道炎症中的作用及其药理学效应。
Chromogranin-A and its derived peptides and their pharmacological effects during intestinal inflammation.
机构信息
Department of Immunology, College of Medicine, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada; IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, OH, USA.
出版信息
Biochem Pharmacol. 2018 Jun;152:315-326. doi: 10.1016/j.bcp.2018.04.009. Epub 2018 Apr 13.
The gastrointestinal tract is the largest endocrine organ that produces a broad range of active peptides. Mucosal changes during inflammation alter the distribution and products of enteroendocrine cells (EECs) that play a role in immune activation and regulation of gut homeostasis by mediating communication between the nervous, endocrine and immune systems. Patients with inflammatory bowel disease (IBD) typically have altered expression of chromogranin (CHG)-A (CHGA), a major soluble protein secreted by EECs that functions as a pro-hormone. CHGA gives rise to several bioactive peptides that have direct or indirect effects on intestinal inflammation. In IBD, CHGA and its derived peptides are correlated with the disease activity. In this review we describe the potential immunomodulatory roles of CHGA and its derived peptides and their clinical relevance during the progression of intestinal inflammation. Targeting CHGA and its derived peptides could be of benefit for the diagnosis and clinical management of IBD patients.
胃肠道是最大的内分泌器官，可产生广泛的活性肽。炎症期间的黏膜变化改变了参与免疫激活和调节肠道内稳态的肠内分泌细胞（EEC）的分布和产物，通过介导神经系统、内分泌系统和免疫系统之间的通讯来实现这一点。患有炎症性肠病（IBD）的患者通常会改变嗜铬粒蛋白 A（CHGA）的表达，CHGA 是 EEC 分泌的主要可溶性蛋白，作为前激素发挥作用。CHGA 产生几种具有直接或间接影响肠道炎症的生物活性肽。在 IBD 中，CHGA 及其衍生肽与疾病活动相关。在这篇综述中，我们描述了 CHGA 及其衍生肽的潜在免疫调节作用及其在肠道炎症进展过程中的临床相关性。针对 CHGA 及其衍生肽可能有益于 IBD 患者的诊断和临床管理。
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