硒蛋白P合成的分子机制。
Molecular mechanism of selenoprotein P synthesis.
作者信息
Shetty Sumangala, Copeland Paul R
机构信息
Department of Biochemistry and Molecular Biology, Rutgers - Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, United States.
Department of Biochemistry and Molecular Biology, Rutgers - Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, United States.
出版信息
Biochim Biophys Acta Gen Subj. 2018 Nov;1862(11):2506-2510. doi: 10.1016/j.bbagen.2018.04.011. Epub 2018 Apr 12.
Abstract
BACKGROUND
Selenoprotein synthesis requires the reinterpretation of a UGA stop codon as one that encodes selenocysteine (Sec), a process that requires a set of dedicated translation factors. Among the mammalian selenoproteins, Selenoprotein P (SELENOP) is unique as it contains a selenocysteine-rich domain that requires multiple Sec incorporation events.
SCOPE OF REVIEW
In this review we elaborate on new data and current models that provide insight into how SELENOP is made.
MAJOR CONCLUSIONS
SELENOP synthesis requires a specific set of factors and conditions.
GENERAL SIGNIFICANCE
As the key protein required for proper selenium distribution, SELENOP stands out as a lynchpin selenoprotein that is essential for male fertility, proper neurologic function and selenium metabolism.
摘要
背景
硒蛋白的合成需要将UGA终止密码子重新解读为编码硒代半胱氨酸（Sec）的密码子，这一过程需要一组特定的翻译因子。在哺乳动物硒蛋白中，硒蛋白P（SELENOP）是独特的，因为它含有一个富含硒代半胱氨酸的结构域，需要多个硒代半胱氨酸掺入事件。
综述范围
在本综述中，我们详细阐述了有助于深入了解SELENOP如何合成的新数据和当前模型。
主要结论
SELENOP的合成需要一组特定的因子和条件。
一般意义
作为硒正确分布所需的关键蛋白质，SELENOP作为一种关键的硒蛋白脱颖而出，对男性生育能力、正常神经功能和硒代谢至关重要。
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