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硒蛋白P合成的分子机制。

Molecular mechanism of selenoprotein P synthesis.

作者信息

Shetty Sumangala, Copeland Paul R

机构信息

Department of Biochemistry and Molecular Biology, Rutgers - Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, United States.

Department of Biochemistry and Molecular Biology, Rutgers - Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, United States.

出版信息

Biochim Biophys Acta Gen Subj. 2018 Nov;1862(11):2506-2510. doi: 10.1016/j.bbagen.2018.04.011. Epub 2018 Apr 12.

DOI:10.1016/j.bbagen.2018.04.011
PMID:29656121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6188828/
Abstract

BACKGROUND

Selenoprotein synthesis requires the reinterpretation of a UGA stop codon as one that encodes selenocysteine (Sec), a process that requires a set of dedicated translation factors. Among the mammalian selenoproteins, Selenoprotein P (SELENOP) is unique as it contains a selenocysteine-rich domain that requires multiple Sec incorporation events.

SCOPE OF REVIEW

In this review we elaborate on new data and current models that provide insight into how SELENOP is made.

MAJOR CONCLUSIONS

SELENOP synthesis requires a specific set of factors and conditions.

GENERAL SIGNIFICANCE

As the key protein required for proper selenium distribution, SELENOP stands out as a lynchpin selenoprotein that is essential for male fertility, proper neurologic function and selenium metabolism.

摘要

背景

硒蛋白的合成需要将UGA终止密码子重新解读为编码硒代半胱氨酸（Sec）的密码子，这一过程需要一组特定的翻译因子。在哺乳动物硒蛋白中，硒蛋白P（SELENOP）是独特的，因为它含有一个富含硒代半胱氨酸的结构域，需要多个硒代半胱氨酸掺入事件。

综述范围

在本综述中，我们详细阐述了有助于深入了解SELENOP如何合成的新数据和当前模型。

主要结论

SELENOP的合成需要一组特定的因子和条件。

一般意义

作为硒正确分布所需的关键蛋白质，SELENOP作为一种关键的硒蛋白脱颖而出，对男性生育能力、正常神经功能和硒代谢至关重要。

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本文引用的文献

1
Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P.多个RNA结构在硒蛋白P合成过程中影响翻译起始和UGA重新定义效率。
Nucleic Acids Res. 2017 Dec 15;45(22):13004-13015. doi: 10.1093/nar/gkx982.
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The RNA-binding protein Secisbp2 differentially modulates UGA codon reassignment and RNA decay.RNA结合蛋白Secisbp2对UGA密码子重新分配和RNA衰变有不同的调节作用。
Nucleic Acids Res. 2017 Apr 20;45(7):4094-4107. doi: 10.1093/nar/gkw1255.
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Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements.具有不同数量硒代半胱氨酸插入序列（SECIS）元件的人硒蛋白P和S变异体mRNA以及来自突变小鼠对多个SECIS元件作用的推断。
Open Biol. 2016 Nov;6(11). doi: 10.1098/rsob.160241.
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Selenocysteine incorporation: A trump card in the game of mRNA decay.硒代半胱氨酸的掺入：mRNA 降解游戏中的一张王牌。
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5
Regulation of selenocysteine incorporation into the selenium transport protein, selenoprotein P.调控硒代半胱氨酸掺入硒转运蛋白硒蛋白 P。
J Biol Chem. 2014 Sep 5;289(36):25317-26. doi: 10.1074/jbc.M114.590430. Epub 2014 Jul 25.
6
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Reconstitution of selenocysteine incorporation reveals intrinsic regulation by SECIS elements.硒半胱氨酸掺入的重建揭示了 SECIS 元件的内在调节。
J Mol Biol. 2013 Jul 24;425(14):2415-22. doi: 10.1016/j.jmb.2013.04.016. Epub 2013 Apr 23.
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Progression of neurodegeneration and morphologic changes in the brains of juvenile mice with selenoprotein P deleted.硒蛋白 P 缺失的幼年小鼠大脑中的神经退行性变和形态变化进展。
Brain Res. 2011 Jun 29;1398:1-12. doi: 10.1016/j.brainres.2011.04.046. Epub 2011 May 5.
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Processive selenocysteine incorporation during synthesis of eukaryotic selenoproteins.真核生物硒蛋白合成过程中的连续硒半胱氨酸掺入。
J Mol Biol. 2010 Jun 11;399(3):385-96. doi: 10.1016/j.jmb.2010.04.033. Epub 2010 Apr 24.
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The human selenoproteome: recent insights into functions and regulation.人类硒蛋白组：功能与调控的最新见解
Cell Mol Life Sci. 2009 Aug;66(15):2457-78. doi: 10.1007/s00018-009-0032-4. Epub 2009 Apr 28.