National Institute for Health Research, Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Acta Ophthalmol. 2018 Nov;96(7):e835-e839. doi: 10.1111/aos.13742. Epub 2018 Apr 15.
To determine the evolution of fundus autofluorescence (FAF) patterns in chronic central serous chorioretinopathy (CSCR) over time.
We retrospectively studied the changes in FAF patterns over time in 157 eyes of 112 patients with chronic CSCR using the Heidelberg Retina Angiography with a 488-nm excitation light and a 500-nm cutoff barrier filter.
The mean duration of follow-up was 37.2 months. The most common baseline pattern was that of granular hypoautofluorescence (51.0%). The earliest change in chronic CSCR is diffuse hyperautofluorescence and it occurs approximately 4 months after the reported first episode. The most common change observed at this stage is a change within areas of hyperautofluorescence where hyper-reflective dots appeared or disappeared. Change in FAF patterns from areas of hyperautofluorescence to hypoautofluorescence was slow. Only 25% of eyes showed such a change in pattern by 36 months. It takes an average of 24 months for granular hypoautofluorescent pattern to develop confluent hypoautofluorescence. There were no predictive patterns for the development of confluent CSCR.
Fundus autofluorescence (FAF) changes in CSCR evolve very gradually and so is not a good outcome measure for clinical trials.
确定慢性中心性浆液性脉络膜视网膜病变（CSCR）患者眼底自发荧光（FAF）模式随时间的演变。
我们使用海德堡视网膜血管造影仪（激发光 488nm，截止滤光片 500nm），对 112 例 157 只眼的慢性 CSCR 患者的 FAF 模式随时间的变化进行了回顾性研究。
平均随访时间为 37.2 个月。最常见的基线模式是颗粒状低自发荧光（51.0%）。慢性 CSCR 的最早变化是弥漫性高自发荧光，大约在首次发作后 4 个月出现。在此阶段观察到的最常见变化是在高自发荧光区域内出现或消失的高反射点。高自发荧光区域向低自发荧光区域的 FAF 模式变化缓慢。到 36 个月时，只有 25%的眼出现这种模式改变。颗粒状低自发荧光模式发展为融合性低自发荧光平均需要 24 个月。融合性 CSCR 的发展没有可预测的模式。
CSCR 的 FAF 变化非常缓慢，因此不是临床试验的良好预后指标。
