Sayed Mohsen A, Ghazy Nahla M, El Sayed Hagar, El-Bassuony Asmaa A H
Botany and Microbiology Department, Faculty of Science, Cairo University, Giza, Egypt.
Dermatology Department, Faculty of Medicine, Kasralainy School of Medicine, Cairo University, Giza, Egypt.
Int Microbiol. 2025 Apr;28(4):811-827. doi: 10.1007/s10123-024-00566-y. Epub 2024 Aug 26.
Dermatophyte infections globally account for 20 to 25% of fungal infections. Dermatophytes have begun exhibiting antifungal drug resistance, making it challenging to treat this particular infection. Essential oils could be used as alternative solutions as they have been used for a long period to treat different infections. The research has demonstrated the antifungal efficacy of cinnamon, clove, lemongrass, tea tree, thyme, and garlic essential oils, and the impact of their combinations was assayed against Microsporum canis, Trichophyton tonsurans, T. violaceum, T. verrucosum, and Epidermophyton floccosum. Polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) was used to identify the most prevalent M. canis. The accession number of M. canis was obtained as ON007275. All tested essential oils exhibited antidermatophytic action except garlic. A synergistic effect was attained by cinnamon + clove, cinnamon + lemongrass, clove + lemongrass, clove + tea tree, and thyme + tea tree combinations. Concerning antifungal activity, M. canis was the most susceptible dermatophytic species, except in the case of thyme T. violaceum, which was the most susceptible dermatophytic species. The maximum inhibition was recorded in the cases of cinnamon and cinnamon + lemongrass combination against M. canis. The least minimum inhibitory concentrations were attained by cinnamon and clove against M. canis, cinnamon + clove against M. canis and T. violaceum, and cinnamon + lemongrass against M. canis, T. violaceum, T. verrucosum, and E. floccosum. The least minimum fungicidal concentration showed by cinnamon against M. canis, cinnamon + clove against M. canis and T. violaceum, cinnamon + lemongrass against M. canis, T. violaceum, T. verrucosum, and E. floccosum, and clove + lemongrass against M. canis.
皮肤癣菌感染在全球真菌感染中占20%至25%。皮肤癣菌已开始表现出抗真菌药物耐药性，这使得治疗这种特定感染具有挑战性。精油可作为替代解决方案，因为它们长期以来一直用于治疗各种感染。该研究已证明肉桂、丁香、柠檬草、茶树、百里香和大蒜精油的抗真菌功效，并检测了它们的组合对犬小孢子菌、断发毛癣菌、紫色毛癣菌、疣状毛癣菌和絮状表皮癣菌的影响。采用聚合酶链反应（PCR）-限制性片段长度多态性（RFLP）来鉴定最常见的犬小孢子菌。犬小孢子菌的登录号为ON007275。除大蒜外，所有测试的精油均表现出抗皮肤癣菌作用。肉桂+丁香、肉桂+柠檬草、丁香+柠檬草、丁香+茶树和百里香+茶树组合产生了协同效应。关于抗真菌活性，犬小孢子菌是最敏感的皮肤癣菌物种，但百里香对紫色毛癣菌的情况除外，紫色毛癣菌是最敏感的皮肤癣菌物种。肉桂和肉桂+柠檬草组合对犬小孢子菌的抑制作用最大。肉桂和丁香对犬小孢子菌、肉桂+丁香对犬小孢子菌和紫色毛癣菌、肉桂+柠檬草对犬小孢子菌、紫色毛癣菌、疣状毛癣菌和絮状表皮癣菌的最低抑菌浓度最低。肉桂对犬小孢子菌、肉桂+丁香对犬小孢子菌和紫色毛癣菌、肉桂+柠檬草对犬小孢子菌、紫色毛癣菌、疣状毛癣菌和絮状表皮癣菌以及丁香+柠檬草对犬小孢子菌的最低杀菌浓度最低。
