Chanu Khangembam Victoria, Thakuria Dimpal, Kumar Satish
ICAR-Directorate of Coldwater Fisheries Research, Bhimtal - 263 136, Uttarakhand, India.
ICAR-Indian Veterinary Research Institute, Bareilly - 243 122, Uttar Pradesh, India.
Vet World. 2018 Feb;11(2):192-200. doi: 10.14202/vetworld.2018.192-200. Epub 2018 Feb 15.
Antimicrobial peptides (AMPs) are highly conserved components of the innate immune system found among all classes of life. Buffalo (), an important livestock for milk and meat production, is known to have a better resistance to many diseases as compared to cattle. They are found to express many AMPs such as defensins, cathelicidins, and hepcidin which play an important role in neutralizing the invading pathogens. Buffalo AMPs exhibit broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Similar to its natural form, synthetic analogs of buffalo AMPs are also antimicrobial against bacteria and even fungus making them a good target for the development of therapeutic antimicrobials. In addition to its antimicrobial effect, AMPs have been demonstrated to have a number of immunomodulatory functions, and their genes are responsive to infections. Further, induction of their gene expression by external factors may help in preventing infectious diseases. This review briefly discusses the AMPs of buffalo identified to date and their possible role in innate immunity.
抗菌肽（AMPs）是在所有生命类别中都存在的先天免疫系统高度保守的组成部分。水牛是一种重要的肉奶兼用家畜，与牛相比，已知其对多种疾病具有更强的抵抗力。人们发现它们能表达许多抗菌肽，如防御素、cathelicidin和铁调素，这些抗菌肽在中和入侵病原体方面发挥着重要作用。水牛抗菌肽对革兰氏阳性菌和革兰氏阴性菌均表现出广谱抗菌活性。与其天然形式相似，水牛抗菌肽的合成类似物也具有抗菌甚至抗真菌作用，这使其成为治疗性抗菌药物开发的良好靶点。除了抗菌作用外，抗菌肽还被证明具有多种免疫调节功能，其基因对感染有反应。此外，外部因素诱导其基因表达可能有助于预防传染病。本文综述简要讨论了迄今为止已鉴定出的水牛抗菌肽及其在先天免疫中的可能作用。
