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一名白种女性患者出现具有皮肤特征的腮腺木村病。

Kimura's disease of the parotid gland with cutaneous features in a Caucasian female patient.

作者信息

Glibbery Natalia, Muscat Kenneth, Cascarini Luke

机构信息

Department of Head and Neck Surgery, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK.

出版信息

J Surg Case Rep. 2018 Apr 9;2018(4):rjy067. doi: 10.1093/jscr/rjy067. eCollection 2018 Apr.

DOI:10.1093/jscr/rjy067
PMID:29657706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5890462/
Abstract

Kimura's disease is a rare disease of unknown aetiology, commonly presenting with slow-growing head and neck subcutaneous nodules, lymphadenopathy, eosinophilia and elevated immunoglobulin E. This report describes a very rare case of a 41-year-old female, of White-British ethnicity, with a new diagnosis of Kimura's disease of the parotid gland and associated cutaneous features. The patient was investigated for 3 years before a diagnosis of Kimura's disease was reached. A superficial parotidectomy was undertaken and no recurrence was observed in the 20 months following surgery. Kimura's disease is easily misdiagnosed, owing to lack of clinical awareness. This case report highlights the troubling symptomatology as well as complexities of diagnosis and management of Kimura's disease. A high level of clinical suspicion is required, for patients of any ethnicity and sex presenting with features consistent with the disease, in order for prompt diagnosis, investigation and management to be achieved.

摘要

木村病是一种病因不明的罕见疾病,通常表现为生长缓慢的头颈部皮下结节、淋巴结病、嗜酸性粒细胞增多和免疫球蛋白E升高。本报告描述了一例非常罕见的病例,患者为41岁的英国白人女性,新诊断为腮腺木村病并伴有相关皮肤表现。该患者在确诊木村病之前接受了3年的检查。进行了腮腺浅叶切除术,术后20个月未观察到复发。由于缺乏临床认识,木村病很容易被误诊。本病例报告强调了木村病令人困扰的症状以及诊断和管理的复杂性。对于任何种族和性别的患者,只要出现与该病相符的特征,都需要高度的临床怀疑,以便能够及时进行诊断、检查和管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/cebf84a4e436/rjy067f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/211430bcd884/rjy067f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/119f8dc7d849/rjy067f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/53d675af4a7f/rjy067f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/9ca431dc8a94/rjy067f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/6bbd1b245128/rjy067f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/cebf84a4e436/rjy067f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/211430bcd884/rjy067f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/119f8dc7d849/rjy067f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/53d675af4a7f/rjy067f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/9ca431dc8a94/rjy067f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/6bbd1b245128/rjy067f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/5890462/cebf84a4e436/rjy067f06.jpg

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本文引用的文献

1
Comparison of Local Recurrence Rate of Three Treatment Modalities for Kimura Disease.木村病三种治疗方式局部复发率的比较
J Craniofac Surg. 2016 Jan;27(1):170-4. doi: 10.1097/SCS.0000000000002337.
2
Kimura's disease: an uncommon cause of head and neck masses with potentially serious sequelae.木村病:一种导致头颈部肿块的罕见病因,可能伴有严重后遗症。
J Surg Case Rep. 2015 Oct 23;2015(10):rjv131. doi: 10.1093/jscr/rjv131.
3
Retrospective Multicentric Study of 25 Kimura Disease Patients: Emphasis on Therapeutics and Shared Features with Cutaneous IgG4-Related Disease.
BMC Surg. 2020 Jan 2;20(1):1. doi: 10.1186/s12893-019-0673-7.
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Eosinophilia and Kidney Disease: More than Just an Incidental Finding?嗜酸性粒细胞增多与肾脏疾病:仅仅是偶然发现吗?
J Clin Med. 2018 Dec 8;7(12):529. doi: 10.3390/jcm7120529.
25例木村病患者的回顾性多中心研究:着重于治疗方法及与皮肤IgG4相关疾病的共同特征
Dermatology. 2015;231(4):367-77. doi: 10.1159/000439346. Epub 2015 Oct 10.
4
Notch-1 and Ki-67 receptor as predictors for the recurrence and prognosis of Kimura's disease.Notch-1和Ki-67受体作为木村病复发和预后的预测指标。
Int J Clin Exp Pathol. 2014 Apr 15;7(5):2402-10. eCollection 2014.
5
Anti-IgE therapy to Kimura's disease: a pilot study.抗IgE疗法治疗木村病:一项试点研究。
Auris Nasus Larynx. 2014 Aug;41(4):384-8. doi: 10.1016/j.anl.2013.12.006. Epub 2014 Jan 7.
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Kimura disease: a case report and review of the literature with a new management protocol.木村病:一例病例报告及文献复习与新的治疗方案
Int J Nephrol. 2011 Mar 7;2010:673908. doi: 10.4061/2010/673908.
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Kimura disease: review of the literature.木村病:文献综述
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8
Kimura disease: diagnosis and prognostic factors.木村病:诊断与预后因素
Otolaryngol Head Neck Surg. 2007 Aug;137(2):306-11. doi: 10.1016/j.otohns.2007.03.027.
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Kimura disease: a clinicopathologic study of 21 cases.木村病:21例临床病理研究
Am J Surg Pathol. 2004 Apr;28(4):505-13. doi: 10.1097/00000478-200404000-00010.
10
In vivo expression of IL-4, IL-5, IL-13 and IFN-gamma mRNAs in peripheral blood mononuclear cells and effect of cyclosporin A in a patient with Kimura's disease.木村病患者外周血单个核细胞中白细胞介素-4、白细胞介素-5、白细胞介素-13和干扰素-γ mRNA的体内表达及环孢素A的作用
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