Obajuluwa Adejoke Olukayode, Akinyemi Ayodele Jacob, Afolabi Olakunle Bamikole, Adekoya Khalid, Sanya Joseph Olurotimi, Ishola Azeez Olakunle
Biological Sciences Department, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
Biochemistry Department, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
Toxicol Rep. 2017 Oct 3;4:530-534. doi: 10.1016/j.toxrep.2017.09.007. eCollection 2017.
Humans in modern society are exposed to an ever-increasing number of electromagnetic fields (EMFs) and some studies have demonstrated that these waves can alter brain function but the mechanism still remains unclear. Hence, this study sought to investigate the effect of 2.5 Ghz band radio-frequency electromagnetic waves (RF-EMF) exposure on cerebral cortex acetylcholinesterase (AChE) activity and their mRNA expression level as well as locomotor function and anxiety-linked behaviour in male rats. Animals were divided into four groups namely; group 1 was control (without exposure), group 2-4 were exposed to 2.5 Ghz radiofrequency waves from an installed WI-FI device for a period of 4, 6 and 8 weeks respectively. The results revealed that WiFi exposure caused a significant increase in anxiety level and affect locomotor function. Furthermore, there was a significant decrease in AChE activity with a concomitant increase in AChE mRNA expression level in WiFi exposed rats when compared with control. In conclusions, these data showed that long term exposure to WiFi may lead to adverse effects such as neurodegenerative diseases as observed by a significant alteration on AChE gene expression and some neurobehavioral parameters associated with brain damage.
现代社会中的人类接触到的电磁场（EMF）数量不断增加，一些研究表明这些波会改变大脑功能，但其机制仍不清楚。因此，本研究旨在探讨2.5吉赫兹频段射频电磁波（RF-EMF）暴露对雄性大鼠大脑皮层乙酰胆碱酯酶（AChE）活性及其mRNA表达水平以及运动功能和焦虑相关行为的影响。动物被分为四组，即：第1组为对照组（未暴露），第2 - 4组分别暴露于安装的WI-FI设备发出的2.5吉赫兹射频波中4周、6周和8周。结果显示，WiFi暴露导致焦虑水平显著升高并影响运动功能。此外，与对照组相比，暴露于WiFi的大鼠中AChE活性显著降低，同时AChE mRNA表达水平升高。总之，这些数据表明，长期暴露于WiFi可能会导致诸如神经退行性疾病等不良影响，这可通过AChE基因表达的显著改变以及一些与脑损伤相关的神经行为参数观察到。
