生酮饮食在成人和儿童胶质瘤治疗管理中的作用：一项系统综述。
The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review.
作者信息
Martin-McGill Kirsty J, Srikandarajah Nisaharan, Marson Anthony G, Tudur Smith Catrin, Jenkinson Michael D
机构信息
Institute of Translational Medicine, University of Liverpool & The Walton Center NHS Foundation Trust, Lower Lane, Liverpool L9 7LJ, UK.
Department of Biostatistics, University of Liverpool, Brownlow Hill, Liverpool L69 3BX, UK.
出版信息
CNS Oncol. 2018 Apr;7(2):CNS17. doi: 10.2217/cns-2017-0030. Epub 2018 Apr 16.
AIM
We performed a systematic review of the evidence for effectiveness and acceptability of different ketogenic diets (KDs) in the therapeutic management of gliomas.
METHODS
The search strategy included searches of seven electronic databases. Data extraction and quality assessment were undertaken independently by two authors.
RESULTS
No randomized clinical trials were identified. Six studies (n = 39) met the eligibility criteria for this review - all were case series or reports and therefore at high risk of bias. All studies reported overall or progression-free survival; however the effectiveness of KD interventions could not be established. Dietary acceptability was not reported.
CONCLUSION
The effectiveness and acceptability of KDs in the management of gliomas is unknown and high quality randomized controlled trials are needed.
目的
我们对不同生酮饮食（KDs）在胶质瘤治疗管理中的有效性和可接受性证据进行了系统评价。
方法
检索策略包括对七个电子数据库进行检索。由两位作者独立进行数据提取和质量评估。
结果
未检索到随机临床试验。六项研究（n = 39）符合本评价的纳入标准——均为病例系列或报告，因此存在较高的偏倚风险。所有研究均报告了总生存期或无进展生存期；然而，KD干预的有效性尚未确定。未报告饮食可接受性。
结论
KDs在胶质瘤管理中的有效性和可接受性尚不清楚，需要高质量的随机对照试验。
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