Cecchi Nicola, Romanelli Roberta, Ricevuti Flavia, Amitrano Marianna, Carbone Maria Grazia, Dinardo Michele, Burgio Ernesto
Clinical Nutrition Unit - A.O.R.N. Santobono-Pausilipon Children's Hospital, Naples, Italy.
Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples, Italy.
Front Nutr. 2023 Aug 8;10:1222908. doi: 10.3389/fnut.2023.1222908. eCollection 2023.
Brain tumors account for 20-25% of pediatric cancers. The most frequent type of brain tumor is Glioma from grade I to grade IV according to the rate of malignancy. Current treatments for gliomas use chemotherapy, radiotherapy, tyrosine kinase inhibitors, monoclonal antibodies and surgery, but each of the treatment strategies has several serious side effects. Therefore, to improve treatment efficacy, it is necessary to tailor therapies to patient and tumor characteristics, using appropriate molecular targets. An increasingly popular strategy is pharmaconutrition, which combines a tailored pharmacological treatment with a diet designed to synergize the effects of drugs. In this review we deal in the molecular mechanisms, the epigenetic effects and modulation of the oxidative stress pathway of ketogenic diets, that underlie its possible role, in the treatment of infantile gliomas, as a complementary approach to conventional cancer therapy.
脑肿瘤占儿童癌症的20%-25%。根据恶性程度，最常见的脑肿瘤类型是I级到IV级的神经胶质瘤。目前治疗神经胶质瘤的方法包括化疗、放疗、酪氨酸激酶抑制剂、单克隆抗体和手术，但每种治疗策略都有一些严重的副作用。因此，为了提高治疗效果，有必要根据患者和肿瘤的特征，利用合适的分子靶点来定制治疗方案。一种越来越流行的策略是药物营养疗法，它将定制的药物治疗与旨在增强药物效果的饮食相结合。在这篇综述中，我们探讨生酮饮食在治疗小儿神经胶质瘤中可能发挥作用的分子机制、表观遗传效应以及对氧化应激途径的调节，作为传统癌症治疗的一种补充方法。
