School of Chinese Medicine , Hong Kong Baptist University , 7 Baptist University Road , Kowloon Tong , Hong Kong, People's Republic of China.
J Agric Food Chem. 2018 May 9;66(18):4581-4583. doi: 10.1021/acs.jafc.8b00493. Epub 2018 Apr 27.
Natural polysaccharides are attracting increasing attention from food and pharmaceutical industries for their wide range of valuable biological activities. However, the poor repeatability of the methods used in sample preparation and chemical characterization is hampering both research and product development. The unstandardized quality, in turn, undermines efforts to understand the mechanism by which they work via oral dose, which is essential to realize the full beneficial potential of polysaccharides. Some scientists believe polysaccharides work by direct gut absorption; however, increasing evidence points to the gut microbiome and intestinal Peyer's patches as holding the keys to how they work.
天然多糖因其广泛的有价值的生物活性而引起食品和制药行业越来越多的关注。然而，样品制备和化学特性化中所用方法的重复性差，这既妨碍了研究，也妨碍了产品开发。质量的不标准化，反过来又破坏了通过口服剂量来了解其作用机制的努力，而这对于实现多糖的全部有益潜力是至关重要的。一些科学家认为多糖通过直接肠道吸收起作用；然而，越来越多的证据表明，肠道微生物组和肠道派尔集合淋巴结是其作用的关键。
