青少年时期的性行为风险与皮质下脑体积。
Sexual risk-taking and subcortical brain volume in adolescence.
机构信息
Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, M/C DC7P, Portland, OR.
Mind Research Network, Albuquerque, NM.
出版信息
Ann Behav Med. 2018 Apr 19;52(5):393-405. doi: 10.1093/abm/kax027.
BACKGROUND
The developmental period of adolescence marks the initiation of new socioemotional and physical behaviors, including sexual intercourse. However, little is known about neurodevelopmental influences on adolescent sexual decision-making.
PURPOSE
We sought to determine how subcortical brain volume correlated with condom use, and whether those associations differed by gender and pubertal development.
METHODS
We used FreeSurfer to extract subcortical volume among N = 169 sexually experienced youth (mean age 16.07 years; 31.95% female). We conducted multiple linear regressions to examine the relationship between frequency of condom use and subcortical volume, and whether these associations would be moderated by gender and pubertal development.
RESULTS
We found that the relationship between brain volume and condom use was better accounted for by pubertal development than by gender, and moderated the association between limbic brain volume and condom use. No significant relationships were observed in reward areas (e.g., nucleus accumbens) or prefrontal cortical control areas.
CONCLUSIONS
These data highlight the potential relevance of subcortical socioemotional processing structures in adolescents' sexual decision-making.
背景
青春期是新的社会情感和生理行为（包括性行为）开始的时期。然而，对于青少年性决策的神经发育影响知之甚少。
目的
我们旨在确定皮质下脑体积与使用避孕套之间的相关性，以及这些相关性是否因性别和青春期发育而不同。
方法
我们使用 FreeSurfer 在 N = 169 名有性经验的年轻人（平均年龄 16.07 岁；31.95%为女性）中提取皮质下体积。我们进行了多次线性回归，以检验使用避孕套的频率与皮质下体积之间的关系，以及这些相关性是否会受到性别和青春期发育的调节。
结果
我们发现，脑体积与避孕套使用之间的关系更多地由青春期发育来解释，而不是由性别来解释，并且调节了边缘脑体积与避孕套使用之间的关系。在奖励区域（例如，伏隔核）或前额皮质控制区域未观察到显著关系。
结论
这些数据突出了皮质下社会情感处理结构在青少年性决策中的潜在相关性。
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