Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
Clin Pharmacol Ther. 2018 May;103(5):732-735. doi: 10.1002/cpt.1052.
Precision medicine-a term widely used in modern medicine-emphasizes the goal to overcome still existing limitations of therapeutic interventions by tailoring medical treatments to individual patient characteristics. Pharmacogenetics was one of the first scientific approaches taking molecular biomarkers into consideration of diagnostics and therapeutic decisions. This issue of Clinical Pharmacology & Therapeutics on the significance of pharmacogenomics inprecision medicine discusses the ongoing challenges on different levels. Access and usage of clinical biobanks, gain of specific information of medication from electronic health records, and tools to combine clinical and molecular information in order to develop advanced clinical decision support are subjects of numerous research initiatives. Implementation in clinical routine, however, remains the subject of evaluation of clinical- and cost-effectiveness, so far.
精准医学——这一术语在现代医学中被广泛应用——强调通过针对个体患者特征定制医疗来克服治疗干预仍存在的局限性的目标。药物遗传学是最早考虑分子生物标志物以用于诊断和治疗决策的科学方法之一。本期《临床药理学与治疗学》讨论了精准医学中药物基因组学的重要意义，并探讨了不同层面上正在面临的挑战。获取临床生物库的途径和使用、从电子健康记录中获取药物的特定信息，以及将临床和分子信息相结合以开发先进的临床决策支持的工具，都是众多研究计划的主题。然而，在临床常规中实施仍然是评估临床和成本效益的主题，到目前为止。
