脂质组学与心血管疾病研究进展
Lipidomic insight into cardiovascular diseases.
机构信息
Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 80045, USA.
Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA; Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA.
出版信息
Biochem Biophys Res Commun. 2018 Oct 7;504(3):590-595. doi: 10.1016/j.bbrc.2018.04.106. Epub 2018 Apr 19.
Abstract
Cardiovascular disease is a primary cause of mortality worldwide. Therefore, it is of major interest to identify sensitive molecular markers that predict cardiovascular events and point to therapeutic strategies that will increase lifespans. Dysregulated lipid metabolism is recognized as an established risk factor in cardiovascular diseases. However, it is still largely unknown which specific lipid molecular species reflect cardiovascular risk. In addition, understanding the whole lipidome signature in vascular pathophysiology is challenging. Recent advancements of mass-spectrometry allow researchers to detect each individual lipid species from unbiased small samples. In this review, we update the current research on lipidomic approaches in cardiovascular diseases.
摘要
心血管疾病是全球范围内主要的致死原因。因此，寻找能够预测心血管事件并指出延长寿命的治疗策略的敏感分子标志物是当务之急。脂质代谢失调被认为是心血管疾病的一个既定风险因素。然而，目前仍不清楚哪些特定的脂质分子种类反映了心血管风险。此外，了解血管病理生理学中的整个脂质组特征也是具有挑战性的。质谱技术的最新进展使得研究人员能够从无偏的小样本中检测到每个单独的脂质种类。在这篇综述中，我们更新了目前在心血管疾病中脂质组学方法的研究进展。
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