Cardiovascular Research Institute (CVRI) Dublin, Mater Private Hospital, D07 WKW8 Dublin, Ireland.
School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland.
Int J Mol Sci. 2022 May 6;23(9):5195. doi: 10.3390/ijms23095195.
Coronary artery ectasia (CAE) is frequently encountered in clinical practice, conjointly with atherosclerotic CAD (CAD). Given the overlapping cardiovascular risk factors for patients with concomitant CAE and atherosclerotic CAD, a common underlying pathophysiology is often postulated. However, coronary artery ectasia may arise independently, as isolated (pure) CAE, thereby raising suspicions of an alternative mechanism. Herein, we review the existing evidence for the pathophysiology of CAE in order to help direct management strategies towards enhanced detection and treatment.
冠状动脉扩张症（CAE）在临床实践中经常遇到，同时伴有动脉粥样硬化性 CAD（CAD）。鉴于同时患有 CAE 和动脉粥样硬化性 CAD 的患者存在重叠的心血管危险因素，通常假设存在共同的潜在病理生理学机制。然而，冠状动脉扩张症也可能独立发生，即单纯性 CAE，从而引起对替代机制的怀疑。在此，我们回顾了 CAE 病理生理学的现有证据，以帮助指导管理策略，从而加强对其的检测和治疗。
