Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
Mol Cells. 2018 May 31;41(5):373-380. doi: 10.14348/molcells.2018.0081. Epub 2018 Apr 18.
Synapses and neural circuits form with exquisite specificity during brain development to allow the precise and appropriate flow of neural information. Although this property of synapses and neural circuits has been extensively investigated for more than a century, molecular mechanisms underlying this property are only recently being unveiled. Recent studies highlight several classes of cell-surface proteins as organizing hubs in building structural and functional architectures of specific synapses and neural circuits. In the present mini-review, we discuss recent findings on various synapse organizers that confer the distinct properties of specific synapse types and neural circuit architectures in mammalian brains, with a particular focus on the hippocampus and cerebellum.
在大脑发育过程中，突触和神经回路以极高的特异性形成，以允许神经信息的精确和适当流动。尽管突触和神经回路的这种特性已经被广泛研究了一个多世纪，但这种特性的分子机制直到最近才被揭示出来。最近的研究强调了几类细胞表面蛋白作为构建特定突触和神经回路结构和功能结构的组织中心。在本综述中，我们讨论了最近在各种突触组织者方面的发现，这些发现赋予了哺乳动物大脑中特定突触类型和神经回路结构的独特特性，特别关注了海马体和小脑。
