Südhof Thomas C
Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, 265 Campus Drive, CA 94305-5453, USA.
Neuron. 2017 Nov 1;96(3):536-541. doi: 10.1016/j.neuron.2017.10.005.
Neuroscience is inherently interdisciplinary in its quest to explain the brain. Like all biological structures, the brain operates at multiple levels, from nano-scale molecules to meter-scale systems. Here, I argue that understanding the nano-scale organization of the brain is not only helpful for insight into its function, but is a requisite for such insight. I propose that one impediment to a better understanding of the brain is that most of its molecular processes are incompletely understood, and suggest a number of key questions that require our attention so that progress can be achieved in neuroscience beyond a description of the activity of neural circuits.
神经科学在解释大脑的过程中本质上是跨学科的。与所有生物结构一样，大脑在多个层面运作，从纳米级分子到米级系统。在此，我认为理解大脑的纳米级组织不仅有助于洞察其功能，而且是获得这种洞察的必要条件。我提出，阻碍更好地理解大脑的一个因素是其大多数分子过程尚未被完全理解，并提出了一些需要我们关注的关键问题，以便在神经科学领域取得超越对神经回路活动描述的进展。
