State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.
School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China.
Sci China Life Sci. 2018 Apr;61(4):448-456. doi: 10.1007/s11427-017-9287-8. Epub 2018 Apr 3.
Hyperthermia has been considered as a promising healing treatment in bone regeneration. We designed a tissue engineering hydrogel based on magnetic nanoparticles to explore the characteristics of hyperthermia for osteogenic regeneration. This nanocomposite hydrogel was successfully fabricated by incorporating magnetic FeO nanoparticles into chitosan/polyethylene glycol (PEG) hydrogel, which showed excellent biocompatibility and were able to easily achieve increasing temperatures under an alternative magnetic field (AMF). With uniformly dispersed nanoparticles, the composite hydrogel resulted in high viability of mesenchymal stem cells (MSCs), and the elevated temperature contributed to the highest osteogenic differentiation ability compared with direct heat treatment applied under equal temperatures. Therefore, the nanoheat stimulation method using the magnetic nanocomposite hydrogel under an AMF may be considered as an alternative candidate in bone tissue engineering regenerative applications.
热疗已被认为是一种有前途的骨再生治疗方法。我们设计了一种基于磁性纳米粒子的组织工程水凝胶，以探索热疗在成骨再生中的特性。通过将磁性 FeO 纳米粒子掺入壳聚糖/聚乙二醇（PEG）水凝胶中，成功制备了这种纳米复合水凝胶，该水凝胶具有优异的生物相容性，并能在交变磁场（AMF）下轻松实现升温。由于纳米粒子均匀分散，复合水凝胶对间充质干细胞（MSCs）具有很高的存活率，与同等温度下直接热处理相比，升高的温度有助于获得最高的成骨分化能力。因此，在交变磁场下使用磁性纳米复合水凝胶进行纳米热刺激的方法可能被认为是骨组织工程再生应用中的一种替代候选方法。
