Woodward Wendy A, Cristofanilli Massimo, Merajver Sofia D, Van Laere Steven, Pusztai Lajos, Bertucci Francois, Berditchevski Fedor, Polyak Kornelia, Overmoyer Beth, Devi Gayathri R, Sterneck Esta, Schneider Robert, Debeb Bisrat G, Wang Xiaoping, van Golen Kenneth L, El-Zein Randa, Rahal Omar M, Alexander Angela, Reuben James M, Krishnamurthy Savitri, Lucci Anthony, Ueno Naoto T
MD Anderson Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, TX.
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
J Cancer. 2017 Oct 9;8(17):3607-3614. doi: 10.7150/jca.21200. eCollection 2017.
In 2006, a remarkable collaboration between University of Texas MD Anderson Cancer Center clinicians and Texas and New Mexico State legislators led to the formation of a dedicated IBC Research Program and Clinic at MD Anderson. This initiative provided funding and infrastructure to foster coordination of an IBC World Consortium of national and international experts, and launch the first ever IBC international conference in 2008, which brought together experts from around the world to facilitate collaborations and accelerate progress. Indeed great progress has been made since then. National and international experts in IBC convened at the 10 Anniversary Conference of the MD Anderson IBC Clinic and Research Program and presented the most extensive sequencing analysis to date comparing IBC to non-IBC, gene- and protein-based immunoprofiling of IBC non-IBC patients, and converging lines of evidence on the specific role of the microenvironment in IBC. Novel models, unique metabolic mechanisms, and prominent survival pathways have been identified and were presented. Multiple clinical trials based on the work of the last decade are in progress or in development. The important challenges ahead were discussed. This progress and a coordinated summary of these works are presented herein.
2006年，德克萨斯大学MD安德森癌症中心的临床医生与德克萨斯州和新墨西哥州的立法者开展了一项意义非凡的合作，促成了MD安德森专门的炎性乳腺癌（IBC）研究项目和诊所的成立。该倡议提供了资金和基础设施，以促进由国内外专家组成的IBC世界联盟的协调，并于2008年举办了有史以来第一次IBC国际会议，汇聚了来自世界各地的专家，以促进合作并加速进展。自那时以来确实取得了巨大进展。IBC领域的国内外专家齐聚MD安德森IBC诊所和研究项目十周年会议，展示了迄今为止最广泛的测序分析，比较了IBC与非IBC，对IBC和非IBC患者进行了基于基因和蛋白质的免疫分析，并就微环境在IBC中的具体作用提供了多条证据。已识别并展示了新模型、独特的代谢机制和重要的生存途径。基于过去十年工作的多项临床试验正在进行或处于研发阶段。讨论了未来面临的重大挑战。本文介绍了这一进展以及这些工作的协调总结。
