Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, RB, The Netherlands.
Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, RB, The Netherlands.
Hum Mol Genet. 2018 Aug 1;27(R2):R187-R194. doi: 10.1093/hmg/ddy137.
A vast, complex and dynamic consortium of microorganisms known as the gut microbiome colonizes the human gut. Over the past few decades, we have developed an increased awareness of its important role in human health. In this review we discuss the role of the gut microbiome in complex diseases and the possible causal scenarios behind its interactions with the host genome and environmental factors. We then propose a new analysis framework that combines a systems biology approach, cross-kingdom integration of multiple levels of omics data, and innovative in vitro models to yield an integrated picture of human host-microbe interactions. This new framework will lay the foundation for the development of the next phase in personalized medicine.
一个庞大、复杂且动态的微生物群落，被称为肠道微生物组，定植于人类肠道中。在过去的几十年中，我们逐渐认识到其在人类健康中的重要作用。在这篇综述中，我们讨论了肠道微生物组在复杂疾病中的作用，以及其与宿主基因组和环境因素相互作用的可能因果关系。然后，我们提出了一个新的分析框架，该框架结合了系统生物学方法、多组学数据的跨领域整合以及创新的体外模型，以获得人类宿主-微生物相互作用的综合图像。这个新框架将为个性化医疗的下一阶段发展奠定基础。
