Department of Microbiology and Immunology, Montana State University, Bozeman.
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
J Infect Dis. 2018 Jul 24;218(5):809-813. doi: 10.1093/infdis/jiy210.
Staphylococcus aureus is a predominant cause of fatal pneumonia following influenza A virus (IAV) infection. Herein we investigate the influence of antecedent IAV infection on S. aureus virulence gene expression. Using a murine model, comparing the USA300 and USA300ΔsaeR/S strains, we demonstrate that S. aureus pathogenesis following IAV infection is SaeR/S dependent. Furthermore, we show that IAV modulates the lung environment to rapidly up-regulate S. aureus virulence factors containing the SaeR-binding domain. Data demonstrate that the pathogen response to IAV infection impacts host outcome and provides evidence that the ability of S. aureus to sense and respond to the lung environment determines severity of pneumonia.
金黄色葡萄球菌是甲型流感病毒（IAV）感染后导致致命性肺炎的主要病原体。在此，我们研究了先前 IAV 感染对金黄色葡萄球菌毒力基因表达的影响。通过使用一种鼠模型，比较 USA300 和 USA300ΔsaeR/S 两种菌株，我们证明了金黄色葡萄球菌在 IAV 感染后的发病机制依赖于 SaeR/S。此外，我们表明 IAV 可调节肺部环境，从而快速上调含有 SaeR 结合域的金黄色葡萄球菌毒力因子。研究数据表明，病原体对 IAV 感染的反应会影响宿主的结果，并提供了证据表明金黄色葡萄球菌感知和响应肺部环境的能力决定了肺炎的严重程度。
