Chittim Carina L, Irwin Stephania M, Balskus Emily P
Department of Chemistry and Chemical Biology , Harvard University , 12 Oxford Street , Cambridge , Massachusetts 02138 , United States.
Biochemistry. 2018 May 8;57(18):2567-2577. doi: 10.1021/acs.biochem.7b01277. Epub 2018 Apr 25.
The human gut contains trillions of microorganisms that play a central role in many aspects of host biology, including the provision of key nutrients from the diet. However, our appreciation of how gut microbes and their extensive metabolic capabilities affect the nutritional status of the human host is in its infancy. In this Perspective, we highlight how recent efforts to elucidate the biochemical basis for gut microbial metabolism of dietary components are reshaping our view of these organisms' roles in host nutrition. Gaining a molecular understanding of gut microbe-nutrient interactions will enhance our knowledge of how diet affects host health and disease, ultimately enabling personalized nutrition and therapeutics.
人类肠道中含有数万亿微生物，它们在宿主生物学的许多方面发挥着核心作用，包括从饮食中提供关键营养素。然而，我们对肠道微生物及其广泛的代谢能力如何影响人类宿主营养状况的认识仍处于起步阶段。在这篇观点文章中，我们强调强调了最近为阐明肠道微生物对饮食成分代谢的生化基础所做的努力，正在重塑我们对这些微生物在宿主营养中作用的看法。从分子层面理解肠道微生物与营养素的相互作用，将增进我们对饮食如何影响宿主健康和疾病的认识，最终实现个性化营养和治疗。
