Ajebli Mohammed, Eddouks Mohamed
Team of Physiology and Endocrine Pharmacpology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco.
Cardiovasc Hematol Disord Drug Targets. 2018;18(3):239-246. doi: 10.2174/1871529X18666180419100823.
Buxus sempervirens L. is used in Morocco as a plant with some medicinal properties including treatment of diabetes and cardiovascular diseases.
The objective of the study was to assess the effect of the aqueous extract of Buxus sempervirens L. (Boxwood) leaves on the blood lipid parameters including total cholesterol, triglycerides, High-Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein Cholesterol (LDL-C) and Very Low-Density Lipoprotein Cholesterol (VLDL-C) in normal and streptozotocininduced diabetic rats. In addition, antioxidant activity of aqueous Buxus sempervirens extract was evaluated by DPPH and FRAP assays.
The results indicated a significant decrease in serum total cholesterol and LDL-C levels, while, no change was observed on triglycerides and VLDL-C values in diabetic rats. Lipid profile of normal animals did not reveal any modification. In addition the aqueous extract of Buxus sempervirens exerted a significant antioxidant activity. Therefore, the results suggest that the aqueous extract of Buxus sempervirens exhibits lipid lowering activity which could be due partially to its antioxidant ability.
In conclusion, Buxus sempervirens leaf extract may be helpful in controlling the development of hyperlipidemia as well as atherosclerosis in diabetic animals.
在摩洛哥，常绿黄杨被用作一种具有多种药用特性的植物，包括用于治疗糖尿病和心血管疾病。
本研究的目的是评估常绿黄杨叶水提取物对正常大鼠和链脲佐菌素诱导的糖尿病大鼠血脂参数的影响，这些参数包括总胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和极低密度脂蛋白胆固醇（VLDL-C）。此外，通过DPPH和FRAP试验评估了常绿黄杨水提取物的抗氧化活性。
结果表明，糖尿病大鼠的血清总胆固醇和LDL-C水平显著降低，而甘油三酯和VLDL-C值未观察到变化。正常动物的血脂谱未显示任何改变。此外，常绿黄杨水提取物具有显著的抗氧化活性。因此，结果表明常绿黄杨水提取物具有降脂活性，这可能部分归因于其抗氧化能力。
总之，常绿黄杨叶提取物可能有助于控制糖尿病动物高脂血症以及动脉粥样硬化病情的发展。
