Department of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, Errachidia-52000, Morocco.
Cardiovasc Hematol Agents Med Chem. 2021;19(1):17-23. doi: 10.2174/1871525718666201013152449.
This study aimed to assess the effect of Scorzanera undulata on plasma lipid profile.
Scorzanera undulata (S. undulata) is a medicinal plant popularly used in the Moroccan pharmacopeia as traditional medicine, particularly to treat diabetes mellitus.
The purpose of this study was to explore the effects of aqueous extract of Scorzanera undulata tubers (AERSU) on lipid profile and atherogenic indices in Wistar rats. Biochemical parameters such as Total Cholesterol (TC), triglycerides (TG), and low-and high-density lipoproteins-cholesterol (LDL and HDL) were assessed. Furthermore, the in vitro antioxidant activity of AERSU was also evaluated.
The effect of tubers aqueous extract (AERSU) of S. undulata (20 mg/kg) on plasma lipid profile was investigated in normal and streptozotocin (STZ)-induced diabetic rats. The aqueous extract was tested for its in vitro antioxidant activity. Besides, cardiovascular parameters were estimated.
Treatment with AERSU significantly improved the weight in diabetic rats and decreased plasma cholesterol, triglycerides, and LDL lipoproteins levels. Furthermore, the extract had a favorable impact on the Atherogenic Index (AI) and Coronary Risk Index (CRI). In addition, AERSU seems to possess a potent in vitro antioxidant activity.
The study demonstrates that aqueous Scorzanera undulate extract exhibits antidyslipidemic and antioxidant activities.
本研究旨在评估 Scorzanera undulata 对血浆脂质谱的影响。
Scorzanera undulata（S. undulata）是一种药用植物，在摩洛哥药典中被广泛用作传统药物，特别是用于治疗糖尿病。
本研究旨在探讨 Scorzanera undulata 块茎的水提物（AERSU）对 Wistar 大鼠脂质谱和动脉粥样硬化指数的影响。评估了总胆固醇（TC）、甘油三酯（TG）和低、高密度脂蛋白胆固醇（LDL 和 HDL）等生化参数。此外，还评估了 AERSU 的体外抗氧化活性。
研究了 S. undulata 块茎的水提物（AERSU）（20mg/kg）对正常和链脲佐菌素（STZ）诱导的糖尿病大鼠血浆脂质谱的影响。测试了水提物的体外抗氧化活性。此外，还估计了心血管参数。
AERSU 治疗可显著改善糖尿病大鼠的体重，并降低血浆胆固醇、甘油三酯和 LDL 脂蛋白水平。此外，该提取物对动脉粥样硬化指数（AI）和冠状动脉风险指数（CRI）有良好的影响。此外，AERSU 似乎具有很强的体外抗氧化活性。
研究表明，水提 Scorzanera undulate 提取物具有抗血脂异常和抗氧化活性。
