Slusher Aaron L, Patterson Virginia T, Schwartz Charles S, Acevedo Edmund O
Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, USA.
Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, USA.
Physiol Behav. 2018 Jul 1;191:116-122. doi: 10.1016/j.physbeh.2018.04.018. Epub 2018 Apr 17.
Prefrontal cortex (PFC)-dependent executive function is enhanced immediately following high intensity interval exercise (HIIE). Brain-derived neurotrophic factor (BDNF) is considered a biomarker associated with enhanced execute functioning capacity at rest and in response to exercise. However, the mechanisms responsible for the acute exercise-induced BDNF response in plasma and serum differ, and it is likely that the utilization of BDNF in plasma and/or serum as a biomarker of improved executive function following HIIE may be limited. Therefore, this study examined the impact of HIIE on the plasma and serum BDNF response to understand the efficaciousness of BDNF as a peripheral biomarker associated with improvements in PFC-dependent executive function. Thirteen healthy males (age: 23.62 ± 1.06 years) participated in a randomized, counterbalanced study, performing the Wisconsin Card Sorting Task (WCST) immediately following a 5-minute seated rest (control) and participation in a HIIE protocol administered two weeks apart. HIIE consisted of ten maximal bouts of all out pedaling on a cycle ergometer for 20 s (separated by 10 s of active recovery) against 5.5% of the subject's body weight. Whole blood was collected for the assessment of BDNF in both plasma and serum. Compared to the control session, HIIE elicited significant improvements in WCST performance, yet improvements in PFC-dependent executive function were independent of BDNF concentrations in plasma and serum. Results from this investigation demonstrate that a single session of low-volume, supramaximal HIIE significantly increases PFC-dependent executive function, thereby providing additional evidence to support the powerful benefits on HIIE on cognitive functioning.
高强度间歇运动（HIIE）后，前额叶皮质（PFC）依赖的执行功能会立即增强。脑源性神经营养因子（BDNF）被认为是一种与静息及运动时执行功能能力增强相关的生物标志物。然而，血浆和血清中急性运动诱导的BDNF反应机制不同，血浆和/或血清中的BDNF作为HIIE后执行功能改善的生物标志物的应用可能有限。因此，本研究考察了HIIE对血浆和血清BDNF反应的影响，以了解BDNF作为与PFC依赖的执行功能改善相关的外周生物标志物的有效性。13名健康男性（年龄：23.62±1.06岁）参与了一项随机、平衡的研究，在5分钟坐姿休息（对照）后立即进行威斯康星卡片分类任务（WCST），并在两周后分别参与HIIE方案。HIIE包括在自行车测力计上进行10次全力蹬踏的最大强度训练，每次20秒（中间间隔10秒的主动恢复），阻力为受试者体重的5.5%。采集全血用于评估血浆和血清中的BDNF。与对照阶段相比，HIIE使WCST表现有显著改善，但PFC依赖的执行功能改善与血浆和血清中的BDNF浓度无关。本研究结果表明，单次低容量、超最大强度的HIIE显著提高了PFC依赖的执行功能，从而为支持HIIE对认知功能的强大益处提供了额外证据。
