Deegan Anthony J, Wang Wendy, Men Shaojie, Li Yuandong, Song Shaozhen, Xu Jingjiang, Wang Ruikang K
Department of Bioengineering, University of Washington, Seattle, Washington, USA.
Department of Ophthalmology, University of Washington, Seattle, Washington, USA.
Quant Imaging Med Surg. 2018 Mar;8(2):135-150. doi: 10.21037/qims.2018.02.07.
imaging of the complex cascade of events known to be pivotal elements in the healing of cutaneous wounds is a difficult but essential task. Current techniques are highly invasive, or lack the level of vascular and structural detail required for accurate evaluation, monitoring and treatment. We aimed to use an advanced optical coherence tomography (OCT)-based angiography (OCTA) technique for the non-invasive, high resolution imaging of cutaneous wound healing.
We used a clinical prototype OCTA to image, identify and track key vascular and structural adaptations known to occur throughout the healing process. Specific vascular parameters, such as diameter and density, were measured to aid our interpretations under a spatiotemporal framework.
We identified multiple distinct, yet overlapping stages, hemostasis, inflammation, proliferation, and remodeling, and demonstrated the detailed vascularization and anatomical attributes underlying the multifactorial processes of dermatologic wound healing.
OCTA provides an opportunity to both qualitatively and quantitatively assess the vascular response to acute cutaneous damage and in the future, may help to ascertain wound severity and possible healing outcomes; thus, enabling more effective treatment options.
对已知在皮肤伤口愈合中起关键作用的复杂事件级联进行成像，是一项艰巨但必不可少的任务。目前的技术具有高度侵入性，或者缺乏准确评估、监测和治疗所需的血管和结构细节水平。我们旨在使用一种基于先进光学相干断层扫描（OCT）的血管造影（OCTA）技术，对皮肤伤口愈合进行非侵入性、高分辨率成像。
我们使用临床原型OCTA对已知在整个愈合过程中发生的关键血管和结构适应性变化进行成像、识别和跟踪。测量特定的血管参数，如直径和密度，以帮助我们在时空框架下进行解释。
我们识别出多个不同但相互重叠的阶段，即止血、炎症、增殖和重塑，并展示了皮肤伤口愈合多因素过程背后的详细血管化和解剖学特征。
OCTA提供了一个定性和定量评估急性皮肤损伤血管反应的机会，未来可能有助于确定伤口严重程度和可能的愈合结果；从而实现更有效的治疗选择。
