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基于无运动可编程扫频光源的大体积物体三维成像的长距离和宽视场光学相干断层扫描

Long-range and wide field of view optical coherence tomography for 3D imaging of large volume object based on akinetic programmable swept source.

作者信息

Song Shaozhen, Xu Jingjiang, Wang Ruikang K

机构信息

University of Washington, Department of Bioengineering, Seattle, Washington 98195, USA.

出版信息

Biomed Opt Express. 2016 Oct 27;7(11):4734-4748. doi: 10.1364/BOE.7.004734. eCollection 2016 Nov 1.

Abstract

Current optical coherence tomography (OCT) imaging suffers from short ranging distance and narrow imaging field of view (FOV). There is growing interest in searching for solutions to these limitations in order to expand further in vivo OCT applications. This paper describes a solution where we utilize an akinetic swept source for OCT implementation to enable ~10 cm ranging distance, associated with the use of a wide-angle camera lens in the sample arm to provide a FOV of ~20 x 20 cm. The akinetic swept source operates at 1300 nm central wavelength with a bandwidth of 100 nm. We propose an adaptive calibration procedure to the programmable akinetic light source so that the sensitivity of the OCT system over ~10 cm ranging distance is substantially improved for imaging of large volume samples. We demonstrate the proposed swept source OCT system for in vivo imaging of entire human hands and faces with an unprecedented FOV (up to 400 cm). The capability of large-volume OCT imaging with ultra-long ranging and ultra-wide FOV is expected to bring new opportunities for in vivo biomedical applications.

摘要

当前的光学相干断层扫描(OCT)成像存在测距距离短和成像视野(FOV)窄的问题。人们越来越有兴趣寻找解决这些限制的方法,以便在体内OCT应用中进一步拓展。本文描述了一种解决方案,即我们利用无运动扫频光源来实现OCT,以实现约10厘米的测距距离,同时在样品臂中使用广角相机镜头来提供约20×20厘米的视野。该无运动扫频光源在中心波长1300纳米、带宽100纳米的条件下工作。我们提出了一种针对可编程无运动光源的自适应校准程序,以便在对大体积样品成像时,显著提高OCT系统在约10厘米测距距离上的灵敏度。我们展示了所提出的扫频光源OCT系统用于对整个人手和面部进行体内成像,具有前所未有的视野(高达400平方厘米)。具有超长测距和超宽视野的大体积OCT成像能力有望为体内生物医学应用带来新机遇。

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Large area robotically assisted optical coherence tomography (LARA-OCT).大面积机器人辅助光学相干断层扫描(LARA-OCT)。
Biomed Opt Express. 2024 May 30;15(6):3993-4009. doi: 10.1364/BOE.525524. eCollection 2024 Jun 1.

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