Department of Pulmonary and Critical Care Medicine, Chia-Yi Chang-Gung Memorial Hospital, Chang-Gung Medical Foundation, Chiayi, Taiwan.
Department of Respiratory Therapy, School of Medicine, Chang-Gung University, Taoyuan, Taiwan.
Influenza Other Respir Viruses. 2018 Sep;12(5):643-648. doi: 10.1111/irv.12566. Epub 2018 Jun 12.
Acute respiratory distress syndrome (ARDS) due to severe influenza A H1N1 pneumonitis would result in impaired pulmonary functions and health-related quality of life (HRQoL) after hospital discharge.
The recovery of pulmonary functions, exercise capacity, and HRQoL in the survivors of ARDS due to 2009 pandemic influenza A H1N1 pneumonitis (H1N1-ARDS) was evaluated in a tertiary teaching hospital in northern Taiwan between May 2010 and June 2011.
Data of spirometry, total lung capacity (TLC), diffusing capacity of carbon monoxide (DL ), and 6-minute walk distance (6MWD) in the patients survived from H1N1-ARDS were collected 1, 3, and 6 months post-hospital discharge. HRQoL was evaluated with St. George respiratory questionnaire (SGRQ).
Nine survivors of H1N1-ARDS in the study period were included. All these patients received 2 months' pulmonary rehabilitation program. Pulmonary functions and exercise capacity included TLC, forced vital capacity (FVC), forced expiratory volume in the first second (FEV ), DL , and 6MWD improved from 1 to 3 months post-hospital discharge. Only TLC had further significant improvement from 3 to 6 months. HRQoL represented as the total score of SGRQ had no significant improvement in the first 3 months but improved significantly from 3 to 6 months post-discharge.
The impaired pulmonary functions and exercise capacity in the survivors of H1N1-ARDS improved soon at 3 months after hospital discharge. Their quality of life had keeping improved at 6 months even though there was no further improvement of their pulmonary functions and exercise capacity.
由严重甲型 H1N1 流感引起的急性呼吸窘迫综合征（ARDS）会导致肺部功能受损和健康相关生活质量（HRQoL）下降，在出院后仍会持续存在。
本研究旨在评估台湾北部某教学医院在 2010 年 5 月至 2011 年 6 月期间收治的 2009 年甲型 H1N1 流感相关 ARDS（H1N1-ARDS）幸存者出院后肺部功能、运动能力和 HRQoL 的恢复情况。
本研究收集了幸存者出院后 1、3 和 6 个月的肺量计、肺总量（TLC）、一氧化碳弥散量（DL ）和 6 分钟步行距离（6MWD）等数据。采用圣乔治呼吸问卷（SGRQ）评估 HRQoL。
研究期间共纳入 9 例 H1N1-ARDS 幸存者，所有患者均接受了 2 个月的肺康复计划。出院后 1 至 3 个月，TLC、用力肺活量（FVC）、第 1 秒用力呼气量（FEV ）、DL 和 6MWD 等肺部功能和运动能力逐渐改善，其中仅 TLC 在出院后 3 至 6 个月时进一步显著改善。SGRQ 总评分代表 HRQoL，在出院后 3 个月内无明显改善，但在出院后 3 至 6 个月时显著改善。
H1N1-ARDS 幸存者出院后 3 个月时受损的肺部功能和运动能力迅速改善，尽管肺部功能和运动能力没有进一步改善，但出院后 6 个月时生活质量仍持续提高。
