Sweet M B, Coelho A, Schnitzler C M, Schnitzer T J, Lenz M E, Jakim I, Kuettner K E, Thonar E J
Department of Orthopaedic Surgery, University of the Witwatersrand, Johannesburg, South Africa.
Arthritis Rheum. 1988 May;31(5):648-52. doi: 10.1002/art.1780310510.
Serum levels of keratan sulfate (KS), measured by an enzyme-linked immunosorbent-inhibition assay, were found to be significantly higher in 31 patients with hypertrophic osteoarthritis (OA) than those in 41 adults without joint disease. Seventy-seven percent of patients with OA, but only 12% of control subjects, had serum levels which were more than 1 SD above the mean of the control group. Following replacement of a single osteoarthritic hip joint, serum KS levels decreased, at first, in all patients. Subsequently, the concentration of serum KS progressively increased; 6 months following surgery, KS levels were similar or close to the preoperative levels in virtually all patients. The results suggest that patients with hypertrophic OA may have a generalized imbalance of cartilage proteoglycan metabolism. Measurements of serum KS are likely to prove most useful in studying this particular subset of patients with generalized OA.
通过酶联免疫吸附抑制试验测定的硫酸角质素（KS）血清水平，在31例肥厚性骨关节炎（OA）患者中显著高于41例无关节疾病的成年人。77%的OA患者血清水平高于对照组均值1个标准差以上，而对照组中仅有12%的受试者如此。在置换单个骨关节炎髋关节后，所有患者的血清KS水平起初均下降。随后，血清KS浓度逐渐升高；术后6个月，几乎所有患者的KS水平与术前水平相似或接近。结果表明，肥厚性OA患者可能存在软骨蛋白聚糖代谢的全身性失衡。血清KS检测在研究这一特定类型的全身性OA患者中可能最为有用。
