Sengupta P, Plantevin O M
Department of Anaesthetics, St Thomas' Hospital, London.
Br J Anaesth. 1988 Apr;60(5):570-3. doi: 10.1093/bja/60.5.570.
Patients admitted for day-case laparoscopy were assigned randomly to receive nitrous oxide-oxygen or oxygen, with enflurane, during a standard anaesthetic technique. Postoperative morbidity, in particular nausea and vomiting, and ability to resume normal activity were assessed over the ensuing 48 h. Supplementary administration of propofol during the operative procedure was required significantly more often (P less than 0.05) in the absence of nitrous oxide. There was no significant difference in the incidence of vomiting before discharge when nitrous oxide was omitted. The incidence and severity of nausea over the 48 h following operation was similar in both groups. There was no difference in analgesic or anti-emetic requirements before discharge and the time taken to resume normal activity was similar. It is concluded that nitrous oxide may be avoided readily in day-case laparoscopy without affecting postoperative morbidity or time taken to return to "street fitness" and normal activity.
接受日间腹腔镜手术的患者在标准麻醉技术下被随机分配接受一氧化二氮 - 氧气或仅接受氧气加安氟醚。在随后的48小时内评估术后发病率，特别是恶心和呕吐情况，以及恢复正常活动的能力。在没有一氧化二氮的情况下，手术过程中显著更频繁地需要补充丙泊酚（P小于0.05）。省略一氧化二氮时，出院前呕吐的发生率没有显著差异。两组术后48小时内恶心的发生率和严重程度相似。出院前的镇痛或止吐需求没有差异，恢复正常活动所需的时间也相似。得出的结论是，在日间腹腔镜手术中可以很容易地避免使用一氧化二氮，而不会影响术后发病率或恢复到“日常健康状态”和正常活动所需的时间。
